Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer

There is a strong rationale for investigating nutritional interventions with docosahexaenoic acid (DHA) in cancer prevention and therapy; however, the effects of DHA on ovarian cancer (OC) have not been well studied. Here, we investigated if DHA alone and in combination with carboplatin reduces OC c...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition and cancer 2022, Vol.ahead-of-print (ahead-of-print), p.1-15
Main Authors: Bilyk, Olena, Hamedi, Bahareh, Dutta, Indrani, Newell, Marnie, Bukhari, Amirali B., Gamper, Armin M., McVea, Rojine C., Liu, Jiahui, Schueler, Julia, Siegers, Gabrielle M., Field, Catherine J., Postovit, Lynne-Marie
Format: Article
Language:English
Subjects:
Animal models
Animals
Apoptosis
Carboplatin
Carboplatin - pharmacology
Carcinoma, Ovarian Epithelial
Cell culture
Cell Cycle
Cell growth
Cell membranes
Cell Proliferation
Diet
Disease Models, Animal
Docosahexaenoic acid
Docosahexaenoic Acids - pharmacology
Female
Humans
Mice
Necrosis
Ovarian cancer
Ovarian Neoplasms - pathology
Phospholipids
Plasma membranes
Reduction
Tumors
Xenografts
Xenotransplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is a strong rationale for investigating nutritional interventions with docosahexaenoic acid (DHA) in cancer prevention and therapy; however, the effects of DHA on ovarian cancer (OC) have not been well studied. Here, we investigated if DHA alone and in combination with carboplatin reduces OC cell growth in vitro. In vivo, we used a high-grade serous OC patient-derived xenograft (PDX) mouse model to investigate if DHA affects OC growth and enhances the anticancer actions of carboplatin. We showed synergistic cell killing by DHA and carboplatin in DHA-resistant Kuramochi and SKOV3 OC cells, which corresponded with increased DHA incorporation into whole-cell membrane phospholipids (P 
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2021.1952453