Optimizing stereotactic radiosurgery in patients with recurrent or residual craniopharyngiomas

• Published in: Journal of neuro-oncology 2021-08, Vol.154 (1), p.113-120
• Main Authors: Ogino, Akiyoshi, Niranjan, Ajay, Kano, Hideyuki, Flickinger, John C., Lunsford, L. Dade
• Format: Article
• Language: English
• Subjects: Adult; Clinical Study; Conformity; Craniopharyngioma - pathology; Craniopharyngioma - radiotherapy; Female; Humans; Male; Medicine; Medicine & Public Health; Multivariate analysis; Neoplasia; Neoplasm Recurrence, Local - radiotherapy; Neoplasm, Residual; Neurology; Oncology; Pituitary; Pituitary Neoplasms - pathology; Pituitary Neoplasms - radiotherapy; Radiosurgery; Treatment Outcome
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/s11060-021-03806-7

Purpose Stereotactic radiosurgery (SRS) is an important management strategy for residual and recurrent craniopharyngiomas. The current study evaluated the factors which affected tumor control and complications in craniopharyngioma SRS. Methods This study includes 53 consecutive patients who underwent single-session SRS for recurrent or residual craniopharyngiomas. The median age was 41 years with 28 male and 25 females. The median tumor volume was 0.63 cm 3 and median margin dose was 12 Gy (range 9–25 Gy). Results The overall 3-, 5-, and 10-year survival rates were 97.8%, 92.7% and 88.5%. The overall 3-, 5-, and 10-year tumor control rates were 81.0%, 72.1%, and 53.4%. In univariate analysis, ≥ 3 mm distance from optic structures (p = 0.002), only solid or cystic tumor type (p = 0.037), and ≥ 12 Gy to ≥ 85% of the tumor (p