Analysis of HSPA1B (+1267A>G) Genetic Polymorphism in Patients with Vibration Disease in Combination with Metabolic Syndrome

• Published in: Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.375-378
• Main Authors: Chernyak, Y. I., Kudaeva, I. V.
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Analysis; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Ecology; Ethylenediaminetetraacetic acid; Gene Expression; Gene Frequency; Gene polymorphism; Genetic analysis; Genetic aspects; Genetic polymorphisms; Genome-Wide Association Study; Genotype; Hand-Arm Vibration Syndrome - complications; Hand-Arm Vibration Syndrome - etiology; Hand-Arm Vibration Syndrome - genetics; Hand-Arm Vibration Syndrome - pathology; Heat shock proteins; Heterozygote; HSP70 Heat-Shock Proteins - blood; HSP70 Heat-Shock Proteins - genetics; Humans; Internal Medicine; Laboratory Medicine; Male; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - genetics; Metabolic Syndrome - pathology; Middle Aged; Occupational Exposure - adverse effects; Pathology; Polymorphism; Polymorphism, Single Nucleotide; Triglycerides - blood; Vibration
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05231-2

In 167 men with vibration syndrome (VS), allele and genotype frequencies of HSPA1B (+1267 A > G ) genetic polymorphism ( rs1061581 ) were studied depending on the type of vibration exposure and on the presence or absence of metabolic syndrome (MetS). The examined subjects were divided into two groups: VS patients ( n =80) and VS+MetS patients ( n =87). The differences in the lipid profiles between groups were revealed against the background of the lack of distinctions in the age of patients for A / G and G / G genotypes carriers. An increase in A / A ( p =0.03) and a decrease in A / G ( p =0.04) genotype frequencies in VS patients caused by hand-transmitted vibration in comparison with those in whom the disease was caused by a combination of hand-transmitted and whole-body vibration were found. The shifts in the frequencies of the above genotypes ( p =0.01) were similar in patients with both types of vibration exposure in the VS+MetS group in comparison with VS group; the carriage of genotypes with the G allele in VS group exceeded that in VS+MetS group ( p =0.01).