Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect

• Published in: Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.370-374
• Main Authors: Burdennyy, A. M., Filippova, E. A., Ivanova, N. A., Lukina, S. S., Pronina, I. V., Loginov, V. I., Fridman, M. V., Kazubskaya, T. P., Utkin, D. O., Braga, E. A., Kushlinskii, N. E.
• Format: Article
• Language: English
• Subjects: Antisense RNA; Biomedical and Life Sciences; Biomedicine; Cancer; Carcinoma, Endometrioid - diagnosis; Carcinoma, Endometrioid - genetics; Carcinoma, Endometrioid - metabolism; Carcinoma, Endometrioid - secondary; Cell Biology; Comparative analysis; Cystadenocarcinoma, Serous - diagnosis; Cystadenocarcinoma, Serous - genetics; Cystadenocarcinoma, Serous - metabolism; Cystadenocarcinoma, Serous - secondary; Development and progression; DNA Methylation; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; Gene regulation; Genes; Genetic aspects; Health aspects; Humans; Internal Medicine; Laboratory Medicine; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mesenchyme; Metastases; Metastasis; Methylation; Neoplasm Grading; Neoplasm Staging; Ovarian cancer; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Pathology; Peritoneal Neoplasms - diagnosis; Peritoneal Neoplasms - genetics; Peritoneal Neoplasms - metabolism; Peritoneal Neoplasms - secondary; Peritoneum; Reversion; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Semaphorins - genetics; Semaphorins - metabolism; Stem cells; Tumors
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05230-3

The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metastasis of ovarian cancer. A multiple and significant ( p