Volume control: Turning the dial on regulatory T cells

Treg-mediated immunosuppression must be tightly regulated to support immunity while limiting tissue damage. In this issue of Cell, Wong et al. and Marangoni et al. use high-resolution imaging to define feedback circuits that quantitatively control local Treg expansion and function. Treg-mediated imm...

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Bibliographic Details
Published in:Cell 2021-07, Vol.184 (15), p.3847-3849
Main Authors: Brown, Chrysothemis C., Gottschalk, Rachel A.
Format: Article
Language:English
Subjects:
Immune Tolerance
Immunosuppression Therapy
T-Lymphocytes, Regulatory - immunology
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Summary:Treg-mediated immunosuppression must be tightly regulated to support immunity while limiting tissue damage. In this issue of Cell, Wong et al. and Marangoni et al. use high-resolution imaging to define feedback circuits that quantitatively control local Treg expansion and function. Treg-mediated immunosuppression must be tightly regulated to support immunity while limiting tissue damage. In this issue of Cell, Wong et al. and Marangoni et al. use high-resolution imaging to define feedback circuits that quantitatively control local Treg expansion and function.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2021.06.015