Effect of ibrutinib treatment on hemolytic anemia and acrocyanosis in cold agglutinin disease/cold agglutinin syndrome

Cold antibody-mediated autoimmune hemolytic anemia (cAIHA) is a rare disease, usually related to an underlying indolent clonal B-cell lymphoproliferative disorder. Jalink and colleagues describe an international retrospective analysis of Bruton tyrosine kinase (BTK) inhibition in patients with cAIHA...

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Bibliographic Details
Published in:Blood 2021-11, Vol.138 (20), p.2002-2005
Main Authors: Jalink, Marit, Berentsen, Sigbjørn, Castillo, Jorge J., Treon, Steven P., Cruijsen, Marjan, Fattizzo, Bruno, Cassin, Ramona, Fotiou, Despina, Kastritis, Efstathios, De Haas, Masja, Oosten, Liesbeth E.M., Frederiksen, Henrik, Patriarca, Andrea, D'Sa, Shirley, Vos, Josephine M.I.
Format: Article
Language:English
Subjects:
Adenine - analogs & derivatives
Adenine - therapeutic use
Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors
Aged
Aged, 80 and over
Anemia, Hemolytic, Autoimmune - complications
Anemia, Hemolytic, Autoimmune - drug therapy
Cyanosis - complications
Cyanosis - drug therapy
Female
Humans
Male
Middle Aged
Piperidines - therapeutic use
Protein Kinase Inhibitors - therapeutic use
Retrospective Studies
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Summary:Cold antibody-mediated autoimmune hemolytic anemia (cAIHA) is a rare disease, usually related to an underlying indolent clonal B-cell lymphoproliferative disorder. Jalink and colleagues describe an international retrospective analysis of Bruton tyrosine kinase (BTK) inhibition in patients with cAIHA. The data indicate a rapid and notable improvement in both the hemolytic anemia as well as acrocyanosis, suggesting that this may be an effective approach, regardless of underlying pathology or MYD88 mutational status.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2021012039