Role of Bacterial Infection in the Development of Acute Liver Failure in Patients with Decompensated Alcoholic Liver Cirrhosis

We examined 74 patients with acute decompensation of alcoholic liver cirrhosis: 34 (45.9%) with bacterial infection (group 1) and 40 (54.1%) without bacterial infection (group 2). The degree and index of acute-on-chronic liver failure (ACLF) were determined using an on-line CLIF-C ACLF Calculator an...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.322-326
Main Authors: Rodina, A. S., Shubina, M. E., Kurbatova, I. V., Dudanova, O. P.
Format: Article
Language:English
Subjects:
Acute-On-Chronic Liver Failure - blood
Acute-On-Chronic Liver Failure - microbiology
Acute-On-Chronic Liver Failure - mortality
Acute-On-Chronic Liver Failure - pathology
Adult
Aspartate Aminotransferases - blood
Bacteria
Bacterial infections
Bacterial Infections - blood
Bacterial Infections - microbiology
Bacterial Infections - mortality
Bacterial Infections - pathology
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Care and treatment
Case-Control Studies
Cell Biology
Chronic infection
Cirrhosis
Cytokeratin
Female
Health aspects
Humans
IL-1β
Infections
Interleukin 4
Interleukin 6
Interleukin 8
Interleukin-1beta - blood
Interleukin-4 - blood
Interleukin-6 - blood
Interleukin-8 - blood
Internal Medicine
Keratin
Keratin-18 - blood
Laboratory Medicine
Liver - metabolism
Liver - pathology
Liver cirrhosis
Liver Cirrhosis, Alcoholic - blood
Liver Cirrhosis, Alcoholic - microbiology
Liver Cirrhosis, Alcoholic - mortality
Liver Cirrhosis, Alcoholic - pathology
Liver failure
Male
Middle Aged
Pathology
Prognosis
Severity of Illness Index
Survival Analysis
Tumor necrosis factor
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-α
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Summary:We examined 74 patients with acute decompensation of alcoholic liver cirrhosis: 34 (45.9%) with bacterial infection (group 1) and 40 (54.1%) without bacterial infection (group 2). The degree and index of acute-on-chronic liver failure (ACLF) were determined using an on-line CLIF-C ACLF Calculator and the levels of cytokeratin-18 fragments, TNFα, IL-1β, IL-4, IL-6, and IL-8. In group 1, AST, cytokeratin-18, TNFα, IL-1β, IL-6, degree and score of ACLF were significantly higher than in group 2. ACLF developed in 18 (52.9%) patients in group 1 and in 11 (27.5%) ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05220-5