A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes

Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluo...

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Bibliographic Details
Published in:Organic letters 2021-08, Vol.23 (15), p.6079-6083
Main Authors: Zhang, Min, Lin, Jin-Hong, Xiao, Ji-Chang
Format: Article
Language:English
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Summary:Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethylsulfonyl–pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azido- or cyano-trifluoromethylation reactions of alkenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02146