Loading…

Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review

Lignin is currently one of the most promising biologically derived resources, due to its abundance and application in biofuels, materials and conversion to value aromatic chemicals. The need to better characterize and understand this complex biopolymer has led to the development of many different an...

Full description

Saved in:
Bibliographic Details
Published in:Mass spectrometry reviews 2023-01, Vol.42 (1), p.144-188
Main Authors: Letourneau, Dane R., Volmer, Dietrich A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063
cites cdi_FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063
container_end_page 188
container_issue 1
container_start_page 144
container_title Mass spectrometry reviews
container_volume 42
creator Letourneau, Dane R.
Volmer, Dietrich A.
description Lignin is currently one of the most promising biologically derived resources, due to its abundance and application in biofuels, materials and conversion to value aromatic chemicals. The need to better characterize and understand this complex biopolymer has led to the development of many different analytical approaches, several of which involve mass spectrometry and subsequent data analysis. This review surveys the most important analytical methods for lignin involving mass spectrometry, first looking at methods involving gas chromatography, liquid chromatography and then continuing with more contemporary methods such as matrix assisted laser desorption ionization and time‐of‐flight‐secondary ion mass spectrometry. Following that will be techniques that directly ionize lignin mixtures—without chromatographic separation—using softer atmospheric ionization techniques that leave the lignin oligomers intact. Finally, ultra‐high resolution mass analyzers such as FT‐ICR have enabled lignin analysis without major sample preparation and chromatography steps. Concurrent with an increase in the resolution of mass spectrometers, there have been a wealth of complementary data analyses and visualization methods that have allowed researchers to probe deeper into the “lignome” than ever before. These approaches extract trends such as compound series and even important analytical information about lignin substructures without performing lignin degradation either chemically or during MS analysis. These innovative methods are paving the way for a more comprehensive understanding of this important biopolymer, as we seek more sustainable solutions for our human species’ energy and materials needs.
doi_str_mv 10.1002/mas.21716
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2555112985</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2741151467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EokNh0RdAltjAIq3_EmfYjSooSK26KKyjG_um4yqJB9-k1XTFI_QZeRLcTmFRqav79-lI9xzGDqQ4lEKoowHoUEkrqxdsIcWyLpSt7Uu2EMrawgpt99gboishpCylfM32tFFLrZRcsHgGRJw26KYUB5zS9s_vuxYIPc_TOnriXUx8WiMHfw2jywe3hgRuwhRuYQpx5DB6TlOa3TQn6PMI_ZYC8djxPlyOYfzMVzzhdcCbt-xVBz3hu8e6z35-_fLj-Ftxen7y_Xh1Wjhd11XhjNeAiLYyumq7DktvugpMq4z2uWmdak0rjZC6rFF1VQu18cqgAMjbSu-zjzvdTYq_ZqSpGQI57HsYMc7UqLLMVqhlXWb0wxP0Ks4p_5Apa-4tM5XN1Kcd5VIkStg1mxQGSNtGiuY-hSan0DykkNn3j4pzO6D_T_6zPQNHO-Am9Lh9Xqk5W13sJP8C202Tgg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2741151467</pqid></control><display><type>article</type><title>Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Letourneau, Dane R. ; Volmer, Dietrich A.</creator><creatorcontrib>Letourneau, Dane R. ; Volmer, Dietrich A.</creatorcontrib><description>Lignin is currently one of the most promising biologically derived resources, due to its abundance and application in biofuels, materials and conversion to value aromatic chemicals. The need to better characterize and understand this complex biopolymer has led to the development of many different analytical approaches, several of which involve mass spectrometry and subsequent data analysis. This review surveys the most important analytical methods for lignin involving mass spectrometry, first looking at methods involving gas chromatography, liquid chromatography and then continuing with more contemporary methods such as matrix assisted laser desorption ionization and time‐of‐flight‐secondary ion mass spectrometry. Following that will be techniques that directly ionize lignin mixtures—without chromatographic separation—using softer atmospheric ionization techniques that leave the lignin oligomers intact. Finally, ultra‐high resolution mass analyzers such as FT‐ICR have enabled lignin analysis without major sample preparation and chromatography steps. Concurrent with an increase in the resolution of mass spectrometers, there have been a wealth of complementary data analyses and visualization methods that have allowed researchers to probe deeper into the “lignome” than ever before. These approaches extract trends such as compound series and even important analytical information about lignin substructures without performing lignin degradation either chemically or during MS analysis. These innovative methods are paving the way for a more comprehensive understanding of this important biopolymer, as we seek more sustainable solutions for our human species’ energy and materials needs.</description><identifier>ISSN: 0277-7037</identifier><identifier>EISSN: 1098-2787</identifier><identifier>DOI: 10.1002/mas.21716</identifier><identifier>PMID: 34293221</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>analytical chemistry ; Biofuels ; Biopolymers ; Chromatography ; Gas chromatography ; HRMS ; Humans ; Ionization ; Ions ; Lignin ; Lignin - chemistry ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Scientific imaging ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><ispartof>Mass spectrometry reviews, 2023-01, Vol.42 (1), p.144-188</ispartof><rights>2021 The Authors. Published by John Wiley &amp; Sons Ltd.</rights><rights>2021 The Authors. Mass Spectrometry Reviews Published by John Wiley &amp; Sons Ltd.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063</citedby><cites>FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34293221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Letourneau, Dane R.</creatorcontrib><creatorcontrib>Volmer, Dietrich A.</creatorcontrib><title>Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review</title><title>Mass spectrometry reviews</title><addtitle>Mass Spectrom Rev</addtitle><description>Lignin is currently one of the most promising biologically derived resources, due to its abundance and application in biofuels, materials and conversion to value aromatic chemicals. The need to better characterize and understand this complex biopolymer has led to the development of many different analytical approaches, several of which involve mass spectrometry and subsequent data analysis. This review surveys the most important analytical methods for lignin involving mass spectrometry, first looking at methods involving gas chromatography, liquid chromatography and then continuing with more contemporary methods such as matrix assisted laser desorption ionization and time‐of‐flight‐secondary ion mass spectrometry. Following that will be techniques that directly ionize lignin mixtures—without chromatographic separation—using softer atmospheric ionization techniques that leave the lignin oligomers intact. Finally, ultra‐high resolution mass analyzers such as FT‐ICR have enabled lignin analysis without major sample preparation and chromatography steps. Concurrent with an increase in the resolution of mass spectrometers, there have been a wealth of complementary data analyses and visualization methods that have allowed researchers to probe deeper into the “lignome” than ever before. These approaches extract trends such as compound series and even important analytical information about lignin substructures without performing lignin degradation either chemically or during MS analysis. These innovative methods are paving the way for a more comprehensive understanding of this important biopolymer, as we seek more sustainable solutions for our human species’ energy and materials needs.</description><subject>analytical chemistry</subject><subject>Biofuels</subject><subject>Biopolymers</subject><subject>Chromatography</subject><subject>Gas chromatography</subject><subject>HRMS</subject><subject>Humans</subject><subject>Ionization</subject><subject>Ions</subject><subject>Lignin</subject><subject>Lignin - chemistry</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Scientific imaging</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><issn>0277-7037</issn><issn>1098-2787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kc1u1DAUhS0EokNh0RdAltjAIq3_EmfYjSooSK26KKyjG_um4yqJB9-k1XTFI_QZeRLcTmFRqav79-lI9xzGDqQ4lEKoowHoUEkrqxdsIcWyLpSt7Uu2EMrawgpt99gboishpCylfM32tFFLrZRcsHgGRJw26KYUB5zS9s_vuxYIPc_TOnriXUx8WiMHfw2jywe3hgRuwhRuYQpx5DB6TlOa3TQn6PMI_ZYC8djxPlyOYfzMVzzhdcCbt-xVBz3hu8e6z35-_fLj-Ftxen7y_Xh1Wjhd11XhjNeAiLYyumq7DktvugpMq4z2uWmdak0rjZC6rFF1VQu18cqgAMjbSu-zjzvdTYq_ZqSpGQI57HsYMc7UqLLMVqhlXWb0wxP0Ks4p_5Apa-4tM5XN1Kcd5VIkStg1mxQGSNtGiuY-hSan0DykkNn3j4pzO6D_T_6zPQNHO-Am9Lh9Xqk5W13sJP8C202Tgg</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Letourneau, Dane R.</creator><creator>Volmer, Dietrich A.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202301</creationdate><title>Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review</title><author>Letourneau, Dane R. ; Volmer, Dietrich A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>analytical chemistry</topic><topic>Biofuels</topic><topic>Biopolymers</topic><topic>Chromatography</topic><topic>Gas chromatography</topic><topic>HRMS</topic><topic>Humans</topic><topic>Ionization</topic><topic>Ions</topic><topic>Lignin</topic><topic>Lignin - chemistry</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Scientific imaging</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Letourneau, Dane R.</creatorcontrib><creatorcontrib>Volmer, Dietrich A.</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley-Blackwell Open Access Backfiles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mass spectrometry reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Letourneau, Dane R.</au><au>Volmer, Dietrich A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review</atitle><jtitle>Mass spectrometry reviews</jtitle><addtitle>Mass Spectrom Rev</addtitle><date>2023-01</date><risdate>2023</risdate><volume>42</volume><issue>1</issue><spage>144</spage><epage>188</epage><pages>144-188</pages><issn>0277-7037</issn><eissn>1098-2787</eissn><abstract>Lignin is currently one of the most promising biologically derived resources, due to its abundance and application in biofuels, materials and conversion to value aromatic chemicals. The need to better characterize and understand this complex biopolymer has led to the development of many different analytical approaches, several of which involve mass spectrometry and subsequent data analysis. This review surveys the most important analytical methods for lignin involving mass spectrometry, first looking at methods involving gas chromatography, liquid chromatography and then continuing with more contemporary methods such as matrix assisted laser desorption ionization and time‐of‐flight‐secondary ion mass spectrometry. Following that will be techniques that directly ionize lignin mixtures—without chromatographic separation—using softer atmospheric ionization techniques that leave the lignin oligomers intact. Finally, ultra‐high resolution mass analyzers such as FT‐ICR have enabled lignin analysis without major sample preparation and chromatography steps. Concurrent with an increase in the resolution of mass spectrometers, there have been a wealth of complementary data analyses and visualization methods that have allowed researchers to probe deeper into the “lignome” than ever before. These approaches extract trends such as compound series and even important analytical information about lignin substructures without performing lignin degradation either chemically or during MS analysis. These innovative methods are paving the way for a more comprehensive understanding of this important biopolymer, as we seek more sustainable solutions for our human species’ energy and materials needs.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34293221</pmid><doi>10.1002/mas.21716</doi><tpages>45</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0277-7037
ispartof Mass spectrometry reviews, 2023-01, Vol.42 (1), p.144-188
issn 0277-7037
1098-2787
language eng
recordid cdi_proquest_miscellaneous_2555112985
source Wiley-Blackwell Read & Publish Collection
subjects analytical chemistry
Biofuels
Biopolymers
Chromatography
Gas chromatography
HRMS
Humans
Ionization
Ions
Lignin
Lignin - chemistry
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Scientific imaging
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
title Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A24%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mass%20spectrometry%E2%80%90based%20methods%20for%20the%20advanced%20characterization%20and%20structural%20analysis%20of%20lignin:%20A%20review&rft.jtitle=Mass%20spectrometry%20reviews&rft.au=Letourneau,%20Dane%20R.&rft.date=2023-01&rft.volume=42&rft.issue=1&rft.spage=144&rft.epage=188&rft.pages=144-188&rft.issn=0277-7037&rft.eissn=1098-2787&rft_id=info:doi/10.1002/mas.21716&rft_dat=%3Cproquest_cross%3E2741151467%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3886-c4d3aeee76436bffe5d4f6a4b243df6abc2b4b1401358e2f6ba84d24e0aa14063%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2741151467&rft_id=info:pmid/34293221&rfr_iscdi=true