Role of biometals in activation of immune cum inflammatory response in ovine ageing eye: a potential model for understanding human geriatric eye diseases

The present study was designed to evaluate the age-related changes in biometal and antimicrobial peptide (cathelicidin) concentration and their role in oxidative cum pro-inflammatory cascade in an ovine animal model. Clinically healthy ovine (n = 126) were grouped as Group I (n = 55, age = up to 3 y...

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Bibliographic Details
Published in:Biometals 2021-10, Vol.34 (5), p.1081-1098
Main Authors: Nabi, S. U., Jan, A., Muzamil, S., Razaq, R., Muhee, A., Ashraf, T., Ahmad, S., Makhdoomi, D. M., Shah, N. Nazir, Syed, Q.
Format: Article
Language:English
Subjects:
Age
Aging
Animal models
Antiinfectives and antibacterials
Antimicrobial peptides
Antioxidants
Aqueous humour
Ascorbic acid
Biochemistry
Biomedical and Life Sciences
Cell Biology
Copper
Cytokines
Eye
Eye diseases
Eye lens
Inflammation
Inflammatory response
Interleukin 1
Interleukin 6
Iron
Lenses
Life Sciences
Magnesium
Markers
Medicine/Public Health
Microbiology
Oxidation
Oxidative stress
Pathogenesis
Pharmacology/Toxicology
Plant Physiology
Superoxide dismutase
Tumor necrosis factor-α
Zinc
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Summary:The present study was designed to evaluate the age-related changes in biometal and antimicrobial peptide (cathelicidin) concentration and their role in oxidative cum pro-inflammatory cascade in an ovine animal model. Clinically healthy ovine (n = 126) were grouped as Group I (n = 55, age = up to 3 years), Group II (n = 52, age = above 3-below 6 years) and Group III (n = 19, age = 6 years above). Samples (aqueous humour and lens of the eye) were collected stored at − 80 °C till further analysis. In aqueous humour, the concentration of zinc (p 
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-021-00331-y