Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue

• Published in: Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.333-337
• Main Authors: Zyuz’kov, G. N., Zhdanov, V. V., Miroshnichenko, L. A., Polyakova, T. Yu, Simanina, E. V., Stavrova, L. A., Danilets, M. G., Agafonov, V. I., Chaikovskii, A. V.
• Format: Article
• Language: English
• Subjects: Animals; Astrocytes; Astrocytes - cytology; Astrocytes - drug effects; Astrocytes - metabolism; Benzothiazoles - pharmacology; Biomedical and Life Sciences; Biomedicine; CD56 Antigen - genetics; CD56 Antigen - metabolism; Cell Biology; Culture Media, Conditioned - pharmacology; Gene Expression Regulation; Glia; Glial cells; Growth factors; Internal Medicine; Kinases; Laboratory Medicine; Lateral Ventricles - cytology; Lateral Ventricles - drug effects; Lateral Ventricles - metabolism; MAP Kinase Kinase 4 - genetics; MAP Kinase Kinase 4 - metabolism; Mice; Mice, Inbred C57BL; Microglial cells; Multipotent Stem Cells - cytology; Multipotent Stem Cells - drug effects; Multipotent Stem Cells - metabolism; Nerve Growth Factors - biosynthesis; Nerve Growth Factors - genetics; Nervous system diseases; Neural cell adhesion molecule; Neural Cell Adhesion Molecules - genetics; Neural Cell Adhesion Molecules - metabolism; Neural stem cells; Neural Stem Cells - cytology; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Neuroglia - cytology; Neuroglia - drug effects; Neuroglia - metabolism; Neuronal-glial interactions; Neurotrophic factors; p53 Protein; Pathology; Pharmacology and Toxicology; Progenitor cells; Protein kinase; Regeneration; Secretion; Signal Transduction; Stem cell transplantation; Stem cells; Subventricular zone; Toluene - analogs & derivatives; Toluene - pharmacology; Transplantation; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05222-3

We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM + cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity.