Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue

We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization o...

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Published in:Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.333-337
Main Authors: Zyuz’kov, G. N., Zhdanov, V. V., Miroshnichenko, L. A., Polyakova, T. Yu, Simanina, E. V., Stavrova, L. A., Danilets, M. G., Agafonov, V. I., Chaikovskii, A. V.
Format: Article
Language:English
Subjects:
Animals
Astrocytes
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - metabolism
Benzothiazoles - pharmacology
Biomedical and Life Sciences
Biomedicine
CD56 Antigen - genetics
CD56 Antigen - metabolism
Cell Biology
Culture Media, Conditioned - pharmacology
Gene Expression Regulation
Glia
Glial cells
Growth factors
Internal Medicine
Kinases
Laboratory Medicine
Lateral Ventricles - cytology
Lateral Ventricles - drug effects
Lateral Ventricles - metabolism
MAP Kinase Kinase 4 - genetics
MAP Kinase Kinase 4 - metabolism
Mice
Mice, Inbred C57BL
Microglial cells
Multipotent Stem Cells - cytology
Multipotent Stem Cells - drug effects
Multipotent Stem Cells - metabolism
Nerve Growth Factors - biosynthesis
Nerve Growth Factors - genetics
Nervous system diseases
Neural cell adhesion molecule
Neural Cell Adhesion Molecules - genetics
Neural Cell Adhesion Molecules - metabolism
Neural stem cells
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neural Stem Cells - metabolism
Neuroglia - cytology
Neuroglia - drug effects
Neuroglia - metabolism
Neuronal-glial interactions
Neurotrophic factors
p53 Protein
Pathology
Pharmacology and Toxicology
Progenitor cells
Protein kinase
Regeneration
Secretion
Signal Transduction
Stem cell transplantation
Stem cells
Subventricular zone
Toluene - analogs & derivatives
Toluene - pharmacology
Transplantation
Tumor proteins
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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cited_by cdi_FETCH-LOGICAL-c473t-eec044202a3801a76df948a94d6d0bd02624a00e1063fe34021f849d2d091c7c3
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container_title Bulletin of experimental biology and medicine
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creator Zyuz’kov, G. N.
Zhdanov, V. V.
Miroshnichenko, L. A.
Polyakova, T. Yu
Simanina, E. V.
Stavrova, L. A.
Danilets, M. G.
Agafonov, V. I.
Chaikovskii, A. V.
description We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM + cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity.
doi_str_mv 10.1007/s10517-021-05222-3
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N. ; Zhdanov, V. V. ; Miroshnichenko, L. A. ; Polyakova, T. Yu ; Simanina, E. V. ; Stavrova, L. A. ; Danilets, M. G. ; Agafonov, V. I. ; Chaikovskii, A. V.</creator><creatorcontrib>Zyuz’kov, G. N. ; Zhdanov, V. V. ; Miroshnichenko, L. A. ; Polyakova, T. Yu ; Simanina, E. V. ; Stavrova, L. A. ; Danilets, M. G. ; Agafonov, V. I. ; Chaikovskii, A. V.</creatorcontrib><description>We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM + cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. 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1573-8221
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subjects Animals
Astrocytes
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - metabolism
Benzothiazoles - pharmacology
Biomedical and Life Sciences
Biomedicine
CD56 Antigen - genetics
CD56 Antigen - metabolism
Cell Biology
Culture Media, Conditioned - pharmacology
Gene Expression Regulation
Glia
Glial cells
Growth factors
Internal Medicine
Kinases
Laboratory Medicine
Lateral Ventricles - cytology
Lateral Ventricles - drug effects
Lateral Ventricles - metabolism
MAP Kinase Kinase 4 - genetics
MAP Kinase Kinase 4 - metabolism
Mice
Mice, Inbred C57BL
Microglial cells
Multipotent Stem Cells - cytology
Multipotent Stem Cells - drug effects
Multipotent Stem Cells - metabolism
Nerve Growth Factors - biosynthesis
Nerve Growth Factors - genetics
Nervous system diseases
Neural cell adhesion molecule
Neural Cell Adhesion Molecules - genetics
Neural Cell Adhesion Molecules - metabolism
Neural stem cells
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neural Stem Cells - metabolism
Neuroglia - cytology
Neuroglia - drug effects
Neuroglia - metabolism
Neuronal-glial interactions
Neurotrophic factors
p53 Protein
Pathology
Pharmacology and Toxicology
Progenitor cells
Protein kinase
Regeneration
Secretion
Signal Transduction
Stem cell transplantation
Stem cells
Subventricular zone
Toluene - analogs & derivatives
Toluene - pharmacology
Transplantation
Tumor proteins
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
title Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue
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