Surgical Remission of Diabetes in a Patient With Mutation of RET Proto-Oncogene

• Published in: AACE clinical case reports 2021, Vol.7 (4), p.256-260
• Main Authors: Concepción Zavaleta, Marcio José, Armas Flórez, Cristian David, Benites Moya, Cesar Joel, Plasencia Dueñas, Esteban Alberto, Ildefonso Najarro, Sofia Pilar, Palomino Taype, Kely, Durand Torres, Ricardo, Massucco Revoredo, Frederick
• Format: Report
• Language: English
• ISSN: 2376-0605
• DOI: 10.1016/j.aace.2021.01.010

OBJECTIVEIn pheochromocytomas, accelerated catecholamine production can cause secondary diabetes. The gene responsible for multiple endocrine neoplasia type 2 (MEN2)-related pheochromocytomas is the RET proto-oncogene. The objective of this report is to describe a unique case of surgical remission of misdiagnosed type 2 diabetes mellitus (T2DM) in a woman with bilateral pheochromocytoma and RET proto-oncogene mutation. METHODSClinical examination, urinary metanephrine level, triple-phase abdominal computed tomography (CT) with adrenal protocol, positron emission tomography with 18F-fluorodeoxyglucose integrated with CT, surgical pathology, and genetic testing were performed. RESULTSA 46-year-old woman with a 5-year history of apparent T2DM complicated by neuropathy, without a contributory family history, presented with occasional headaches, weight loss, and abdominal pain. A 24-hour urinary metanephrine of 5 mg (reference range, 0.05-1 mg) was found. Abdominal CT showed bilateral adrenal masses with