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β2-adrenoreceptors control human skin microvascular reactivity

Background Topical αd- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and phar...

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Bibliographic Details
Published in:EJD. European journal of dermatology 2021-06, Vol.31 (3), p.326-334
Main Authors: Morell, Anselm, Milara, Javier, Gozalbes, Laurabel, Gavaldà, Amedeu, Tarrasón, Gema, Godessart, Nuria, Marín, Severiano, Navalón, Pedro, Cortijo, Julio
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Language:English
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Summary:Background Topical αd- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and pharmacodynamic data pertaining to these receptors in skin micro-vessels are lacking. Objectives To analyse the expression of different adrenergic receptors and their contribution to vasoreactivity in skin micro-vessels. Materials & Methods Small arteries (500–800 µm) and arterioles (
ISSN:1167-1122
1952-4013
DOI:10.1684/ejd.2021.4068