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β2-adrenoreceptors control human skin microvascular reactivity
Background Topical αd- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and phar...
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Published in: | EJD. European journal of dermatology 2021-06, Vol.31 (3), p.326-334 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Topical αd- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and pharmacodynamic data pertaining to these receptors in skin micro-vessels are lacking.
Objectives
To analyse the expression of different adrenergic receptors and their contribution to vasoreactivity in skin micro-vessels.
Materials & Methods
Small arteries (500–800 µm) and arterioles ( |
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ISSN: | 1167-1122 1952-4013 |
DOI: | 10.1684/ejd.2021.4068 |