Fertility preservation immediately after therapeutic abortion results in multiple normal follicular growth with the absence of mature oocytes due to early luteinization: a case report and literature review

Cancer therapy has priority over fertility preservation. The time available for fertility preservation in patients with cancer is often very limited and depends on the condition of the underlying disease. This case report presents the results of two rounds of controlled ovarian stimulations (COSs) p...

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Bibliographic Details
Published in:Gynecological endocrinology 2021-11, Vol.37 (11), p.1050-1053
Main Authors: Hamada, Haru, Hayama, Tomonari, Ijuin, Akifumi, Miyakoshi, Ai, Kasai, Michi, Tochihara, Shiori, Saito, Marina, Nishi, Mayuko, Ueno, Hiroe, Yamamoto, Mizuki, Komeya, Mitsuru, Yumura, Yasushi, Sakakibara, Hideya, Miyagi, Etsuko, Murase, Mariko
Format: Article
Language:English
Subjects:
Abortion, Induced
Female
Fertility Preservation
Humans
Luteinization
Oocyte Retrieval
Ovulation Induction
Pregnancy
Young Adult
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Summary:Cancer therapy has priority over fertility preservation. The time available for fertility preservation in patients with cancer is often very limited and depends on the condition of the underlying disease. This case report presents the results of two rounds of controlled ovarian stimulations (COSs) performed after an induced abortion. The patient had mixed phenotype acute leukemia diagnosed during early pregnancy and underwent a surgical abortion, followed by ovarian stimulation using urinary follicle-stimulating hormone (uFSH) and gonadotropin-releasing hormone (GnRH) agonists. Oocyte retrieval was subsequently performed for oocyte cryopreservation. Despite good hormonal and ultrasonic follicular growth, no oocytes were obtained. During a second COS performed at a low human chorionic gonadotropin (hCG) level (less than 100 IU/L), several mature oocytes were obtained, suggesting that higher hCG levels during COS induce the absence of mature oocytes during normal follicular growth. It is recommended to start COS post-abortion after confirming a low hCG level while considering the timing of cancer treatment.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2021.1950135