Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis

Objective Porphyromonas ( P .) species (spp.) are a major etiological agent of apical periodontitis (AP), which in turn represents a risk factor for cardiovascular diseases. This study explored the associations between endodontic infection with Porphyromonas species, the systemic bacterial burden, a...

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Published in:Clinical oral investigations 2022, Vol.26 (1), p.993-1001
Main Authors: Jiménez, Constanza, Garrido, Mauricio, Pussinen, Pirkko, Bordagaray, María José, Fernández, Alejandra, Vega, Claudia, Chaparro, Alejandra, Hoare, Anilei, Hernández, Marcela
Format: Article
Language:English
Subjects:
Antibodies
Biofilms
Blood pressure
C-reactive protein
Cardiovascular Diseases
Cross-Sectional Studies
Dentistry
DNA, Bacterial
Endodontics
Endotoxemia
Endotoxins
Enzyme-linked immunosorbent assay
Gum disease
Heart Disease Risk Factors
Humans
Immunoglobulin G
Infections
Inflammation
Medicine
Original Article
Patients
Periapical Periodontitis
Periodontitis
Porphyromonas
Porphyromonas - genetics
Proteins
Risk Factors
Species
Teeth
Young Adult
Young adults
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Summary:Objective Porphyromonas ( P .) species (spp.) are a major etiological agent of apical periodontitis (AP), which in turn represents a risk factor for cardiovascular diseases. This study explored the associations between endodontic infection with Porphyromonas species, the systemic bacterial burden, and cardiovascular risk, based on high-sensitivity C-reactive protein (hsCRP), in young adults with AP. Materials and methods Cross-sectional study. Otherwise, healthy individuals with AP and controls ( n  = 80, ≤ 40 years) were recruited at the University Dental Clinic. Oral parameters and classic cardiovascular risk factors were registered. Endodontic Porphyromonas endodontalis and Porphyromonas gingivalis were identified using conventional PCR. Serum concentrations of anti- P. endodontalis and anti -P. gingivalis antibodies, and endotoxins were determined through ELISA and Limulus-amebocyte assays. Serum hsCRP was determined for cardiovascular risk stratification. Results Intracanal detection of P. endodontalis and P. gingivalis in AP were 33.3% and 22.9%, respectively. Serum anti- P. endodontalis and anti- P. gingivalis IgG was higher in AP than controls ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-021-04083-4