Treatment of children with acute lymphoblastic leukemia in Cambodia

We report a retrospective analysis of 110 unselected pediatric patients with acute lymphoblastic leukemia (ALL) treated during 2015–2017 in a charity‐funded public institution in Cambodia with a reduced intensity ALL‐Moscow Berlin (MB)‐91 protocol. No patient abandoned treatment. Sixty‐three patient...

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Bibliographic Details
Published in:Pediatric blood & cancer 2021-10, Vol.68 (10), p.e29184-n/a
Main Authors: Küpfer, Laura, Meng, Bun, Laurent, Denis, Zimmermann, Martin, Niggli, Felix, Bourquin, Jean‐Pierre, Malene, Iv
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
ALL‐MB‐91
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cambodia
Cambodia - epidemiology
Child
Disease-Free Survival
Hematology
Humans
Leukemia
low‐middle income country
Lymphatic leukemia
Oncology
Patients
pediatric acute lymphoblastic leukemia
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Prognosis
Remission
Remission Induction
Retrospective Studies
Survival
Treatment Outcome
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Summary:We report a retrospective analysis of 110 unselected pediatric patients with acute lymphoblastic leukemia (ALL) treated during 2015–2017 in a charity‐funded public institution in Cambodia with a reduced intensity ALL‐Moscow Berlin (MB)‐91 protocol. No patient abandoned treatment. Sixty‐three patients (57%) were high risk (HR). Seventy‐two patients (65.5%) reached complete remission (CR) on day 36. The 3‐year event‐free survival (EFS) and overall survival (OS) was 34.9% (50.5% for standard risk [SR]). Most deaths resulted from infections (40 [53.3%]) and bleeding (15 [20%]). With further selective reduction of treatment intensity and access to platelet infusion, leukemia therapy is justified in this setting.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.29184