Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children

Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C. This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2021-10, Vol.148 (4), p.1
Main Authors: Capone, Christine A, Misra, Nilanjana, Ganigara, Madhusudan, Epstein, Shilpi, Rajan, Sujatha, Acharya, Suchitra S, Hayes, Denise A, Kearney, Mary Beth, Romano, Angela, Friedman, Richard A, Blaufox, Andrew D, Cooper, Rubin, Schleien, Charles, Mitchell, Elizabeth
Format: Article
Language:English
Subjects:
Adolescent
Aneurysm
Aneurysms
Cardiovascular diseases
Care and treatment
Child
Child, Preschool
Children
Continuum of care
Coronary Aneurysm - etiology
Coronary artery
Coronary Vessels - pathology
COVID-19 - complications
COVID-19 - drug therapy
Edema
Female
Fibrosis
Heart
Heart - diagnostic imaging
Humans
Immunomodulating Agents - therapeutic use
Immunomodulation
Infant
Inflammation
Longitudinal Studies
Magnetic Resonance Imaging
Male
Methods
Multisystem inflammatory syndrome in children
Myocarditis - drug therapy
Myocarditis - etiology
Patient outcomes
Patients
Pediatric multisystem inflammatory syndrome
Pediatric research
Pediatrics
Risk factors
Systemic Inflammatory Response Syndrome - complications
Systemic Inflammatory Response Syndrome - drug therapy
Vasoactive agents
Ventricle
Ventricular Dysfunction, Left - etiology
Ventricular Function, Left - drug effects
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Summary:Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C. This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from April 17 to June 20, 2020. Patients were followed ∼2 weeks, 8 weeks, and 6 months postadmission, with those with coronary aneurysms evaluated more frequently. Acutely, 31 (62%) patients required intensive care with vasoactive support, 26 (52%) had left ventricular (LV) systolic dysfunction, 16 (32%) had LV diastolic dysfunction, 8 (16%) had coronary aneurysms score ≥2.5), and 4 (8%) had coronary dilation score
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2021-050973