Nonenhanced Chemical Exchange Saturation Transfer Cardiac Magnetic Resonance Imaging in Patients With Amyloid Light‐Chain Amyloidosis

Background Chemical exchange saturation transfer (CEST) is an emerging metabolic MRI technique to map creatine distribution in the myocardium. Purpose To investigate the feasibility of using a contrast‐free CEST technique to evaluate cardiac involvement in amyloid light‐chain (AL) amyloidosis. Study...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2022-02, Vol.55 (2), p.567-576
Main Authors: Li, Xiao, Huang, Sisi, Han, Pei, Zhou, Zhengwei, Azab, Linda, Lu, Meng, Li, Jian, An, Jing, Cao, Yihan, Jin, Zhengyu, Li, Debiao, Wang, Yining
Format: Article
Language:English
Subjects:
Adult
Aged
amyloid light chain amyloidosis
Amyloidosis
Biopsy
cardiac magnetic resonance
Cellular structure
Chains
Chemical exchange saturation transfer imaging
Contrast Media
Coronary artery disease
Creatine
Evaluation
Field strength
Gadolinium
Heart diseases
Humans
Immunoglobulin Light-chain Amyloidosis
Inversion
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine
Male
Males
Medical imaging
Middle Aged
Myocardium
Population studies
Predictive Value of Tests
Prospective Studies
Recovery
Saturation
Septum
Statistical analysis
Statistical tests
Structure-function relationships
Variance analysis
Ventricle
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Summary:Background Chemical exchange saturation transfer (CEST) is an emerging metabolic MRI technique to map creatine distribution in the myocardium. Purpose To investigate the feasibility of using a contrast‐free CEST technique to evaluate cardiac involvement in amyloid light‐chain (AL) amyloidosis. Study type Prospective. Population Forty patients with biopsy‐proven AL amyloidosis (age 57.6 ± 9.1 years, 31 males) and 20 healthy controls (age 42.8 ± 13.8 years, 13 males). Field strength/Sequence A 3.0 T, CEST imaging using a single‐shot FLASH sequence, T1 mapping with a modified Look‐Locker inversion recovery sequence and late gadolinium enhancement (LGE) imaging with a phase‐sensitive inversion recovery gradient echo sequence. Assessment The average CEST was calculated in the basal short‐axis slice of the entire left ventricle and septum. LGE was assessed subjectively (none/patchy/global) and extracellular volume (ECV), CEST and T1 maps generated. Statistical Tests Comparison between patient groups and healthy controls was performed by one‐way analysis of variance with post hoc Bonferroni correction. Correlation was assessed using the Pearson's r correlation or Spearman ρ correlation. Statistical significance was defined as P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.27859