Breast cancer diagnosed in the post-weaning period is indicative for a poor outcome

In young women, a breast cancer diagnosis after childbirth increases the risk for metastasis and death. Studies in rodents suggest that post-weaning mammary gland involution contributes to the poor prognosis of postpartum breast cancers. However, this association has not been investigated in humans,...

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Bibliographic Details
Published in:European journal of cancer (1990) 2021-09, Vol.155, p.13-24
Main Authors: Lefrère, Hanne, Floris, Giuseppe, Schmidt, Marjanka K., Neven, Patrick, Warner, Ellen, Cardonick, Elyce, Peccatori, Fedro A., Loibl, Sibylle, Maggen, Charlotte, De Mulder, Hanne, Jerzak, Katarzyna J., Lambrechts, Diether, Lenaerts, Liesbeth, Amant, Frédéric
Format: Article
Language:English
Subjects:
Adult
Breast cancer
Breast feeding
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breastfeeding & lactation
Childbirth & labor
Cohort Studies
Death
Diagnosis
Female
Health hazards
Humans
Invasiveness
Involution
Lactation
Mammary gland
Mammary glands
Metastases
Metastasis
Mortality
Patients
Post-weaning
Postpartum
Postpartum breast cancer
Postpartum Period - physiology
Pregnancy
Pregnancy Complications, Neoplastic - diagnosis
Pregnancy Complications, Neoplastic - mortality
Prognosis
Retrospective Studies
Risk
Statistical models
Survival Analysis
Tumors
Weaning
Womens health
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Summary:In young women, a breast cancer diagnosis after childbirth increases the risk for metastasis and death. Studies in rodents suggest that post-weaning mammary gland involution contributes to the poor prognosis of postpartum breast cancers. However, this association has not been investigated in humans, mainly because of missing information on the patient's lactation status at diagnosis. Clinicopathological data of 1180 young women with primary invasive breast cancer, diagnosed within 2 years postpartum (PP-BC), during pregnancy (Pr-BC), or nulliparous (NP-BC), were collected. For PP-BC patients, breastfeeding history was retrieved to differentiate breast cancers identified during lactation (PP-BCDL) from those diagnosed post-weaning (PP-BCPW). Differences in prognostic parameters, first site of distant metastasis, and risks for metastasis and death were determined between patient groups. Cox proportional hazard models pointed to a twofold increased the risk of metastasis and death in PP-BCPW patients compared with PP-BCDL (hazard ratio [HR] 2.1 [PDRS = 0.021] and 2.9 [POS = 0.004]), Pr-BC (HR 2.1 [PDRS
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2021.06.009