Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients

Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the serum Tsukushi levels in newly diagnosed type 2 diabetes, explorin...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2021-08, Vol.178, p.108987-108987, Article 108987
Main Authors: Li, Yan-Yan, Wu, Xu-Nan, Deng, Xia, Zhang, Pan-Pan, Li, Hao-Xiang, Chen, Ke, Wu, Dan-Ping, Gu, Tian, Wang, Chen-Xi, Zhao, Li, Wang, Dong, Yang, Ling, Yuan, Guo-Yue
Format: Article
Language:English
Subjects:
Diabetes
Insulin resistance
Tsukushi
Type 2
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Summary:Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters. A total of 172 participants were recruited, including 86 patients with newly diagnosed type 2 diabetes and 86 subjects with normal glucose tolerance according to oral glucose tolerance test. Serum Tsukushi was measured by ELISA. The insulin resistance, pancreas β-cell function and insulin sensitivity were determined by homeostasis model assessment (HOMA-IR, HOMA-β), Stumvoll insulin sensitivity index (ISIstumvoll) and Stumvoll metabolic clearance rate (MCRstumvoll). Serum Tsukushi was significantly higher in type 2 diabetes than in normal glucose tolerance [1.22(0.86,1.74) vs 0.8(0.5,1.38) ng/mL; P 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2021.108987