Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy

Abstract Objective We aimed to determine the influences of surgical procedures on the postoperative death of octogenarians with clinical Stage IA non-small cell lung cancer excluding cT1mi. Methods We compared overall survival and the cumulative incidence of death due to all and other causes among 1...

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Published in:Japanese journal of clinical oncology 2021-10, Vol.51 (10), p.1561-1569
Main Authors: Mimae, Takahiro, Miyata, Yoshihiro, Yoshimura, Kenichi, Tsutani, Yasuhiro, Imai, Kentaro, Ito, Hiroyuki, Nakayama, Haruhiko, Ikeda, Norihiko, Okada, Morihito
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container_title Japanese journal of clinical oncology
container_volume 51
creator Mimae, Takahiro
Miyata, Yoshihiro
Yoshimura, Kenichi
Tsutani, Yasuhiro
Imai, Kentaro
Ito, Hiroyuki
Nakayama, Haruhiko
Ikeda, Norihiko
Okada, Morihito
description Abstract Objective We aimed to determine the influences of surgical procedures on the postoperative death of octogenarians with clinical Stage IA non-small cell lung cancer excluding cT1mi. Methods We compared overall survival and the cumulative incidence of death due to all and other causes among 1 130 279, and 191 consecutive patients aged ≤79 and ≥80 years after lobectomy, segmentectomy and wedge resection at three institutions. Death due to other causes was defined as death due to any cause except non-small cell lung cancer. Results The median followup was 53 months. The 5-year overall survival rates for patients aged ≥ 80 and ≤ 79 years after lobectomy, segmentectomy and wedge resection were respectively, 78.0% (95% confidence interval, 63.8%–87.2%) versus 91.2% (95% confidence interval, 89.0%–92.9%), 68.1% (95% confidence interval, 45.2%–83.1%) versus 90.0% (95% confidence interval, 84.6%–93.5%), and 62.7% (95% confidence interval, 44.0–76.7%) versus 84.4% (95% confidence interval, 76.3%–89.9%) (P 
doi_str_mv 10.1093/jjco/hyab122
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Methods We compared overall survival and the cumulative incidence of death due to all and other causes among 1 130 279, and 191 consecutive patients aged ≤79 and ≥80 years after lobectomy, segmentectomy and wedge resection at three institutions. Death due to other causes was defined as death due to any cause except non-small cell lung cancer. Results The median followup was 53 months. The 5-year overall survival rates for patients aged ≥ 80 and ≤ 79 years after lobectomy, segmentectomy and wedge resection were respectively, 78.0% (95% confidence interval, 63.8%–87.2%) versus 91.2% (95% confidence interval, 89.0%–92.9%), 68.1% (95% confidence interval, 45.2%–83.1%) versus 90.0% (95% confidence interval, 84.6%–93.5%), and 62.7% (95% confidence interval, 44.0–76.7%) versus 84.4% (95% confidence interval, 76.3%–89.9%) (P &lt; 0.01 for all). The cumulative incidence of death due to other causes after wedge resection was similar between patients aged ≥ 80 and ≤ 79 years (P = 0.45), but significantly higher in those aged ≥ 80, than ≤ 79 years after lobectomy or segmentectomy (P = 0.00015 and 0.00091, respectively). Conclusions The influence of wedge resection on death due to other causes was lower than that of lobectomy or segmentectomy in patients with non-small cell lung cancer aged ≥ 80 years. Wedge resection might be a useful option for octogenarians even if they can tolerate lobectomy/segmentectomy to avoid postoperative death due to causes other than non-small cell lung cancer. This study provides useful information with which to determine optimal surgical procedures for patients aged ≥ 80 years. Wedge resection is useful for octogenarians with non-small cell lung cancer, especially considering postoperative death due to other causes.</description><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyab122</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Japanese journal of clinical oncology, 2021-10, Vol.51 (10), p.1561-1569</ispartof><rights>The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-fbabbd7ae0d56da74c56f5baaa36088f0e68fb6f50fcc0d03aee806363ee6a7b3</citedby><cites>FETCH-LOGICAL-c362t-fbabbd7ae0d56da74c56f5baaa36088f0e68fb6f50fcc0d03aee806363ee6a7b3</cites><orcidid>0000-0001-9993-8928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Mimae, Takahiro</creatorcontrib><creatorcontrib>Miyata, Yoshihiro</creatorcontrib><creatorcontrib>Yoshimura, Kenichi</creatorcontrib><creatorcontrib>Tsutani, Yasuhiro</creatorcontrib><creatorcontrib>Imai, Kentaro</creatorcontrib><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Nakayama, Haruhiko</creatorcontrib><creatorcontrib>Ikeda, Norihiko</creatorcontrib><creatorcontrib>Okada, Morihito</creatorcontrib><title>Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy</title><title>Japanese journal of clinical oncology</title><description>Abstract Objective We aimed to determine the influences of surgical procedures on the postoperative death of octogenarians with clinical Stage IA non-small cell lung cancer excluding cT1mi. Methods We compared overall survival and the cumulative incidence of death due to all and other causes among 1 130 279, and 191 consecutive patients aged ≤79 and ≥80 years after lobectomy, segmentectomy and wedge resection at three institutions. Death due to other causes was defined as death due to any cause except non-small cell lung cancer. Results The median followup was 53 months. The 5-year overall survival rates for patients aged ≥ 80 and ≤ 79 years after lobectomy, segmentectomy and wedge resection were respectively, 78.0% (95% confidence interval, 63.8%–87.2%) versus 91.2% (95% confidence interval, 89.0%–92.9%), 68.1% (95% confidence interval, 45.2%–83.1%) versus 90.0% (95% confidence interval, 84.6%–93.5%), and 62.7% (95% confidence interval, 44.0–76.7%) versus 84.4% (95% confidence interval, 76.3%–89.9%) (P &lt; 0.01 for all). The cumulative incidence of death due to other causes after wedge resection was similar between patients aged ≥ 80 and ≤ 79 years (P = 0.45), but significantly higher in those aged ≥ 80, than ≤ 79 years after lobectomy or segmentectomy (P = 0.00015 and 0.00091, respectively). Conclusions The influence of wedge resection on death due to other causes was lower than that of lobectomy or segmentectomy in patients with non-small cell lung cancer aged ≥ 80 years. Wedge resection might be a useful option for octogenarians even if they can tolerate lobectomy/segmentectomy to avoid postoperative death due to causes other than non-small cell lung cancer. This study provides useful information with which to determine optimal surgical procedures for patients aged ≥ 80 years. Wedge resection is useful for octogenarians with non-small cell lung cancer, especially considering postoperative death due to other causes.</description><issn>1465-3621</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM9OwzAMxiMEEmNw4wFygwNlabOm5Ygm_klISAjOlZM6bUebjCTVtMfgjcnUHThxsf1ZP1v2R8hlym5TdscX67Wyi3YHMs2yIzJLlyJPuMjS4z_1KTnzfs0Yy8tlMSM_753_olbTGiG0tB6RBkttaNFRBaNHTztPe7uNGgZrGmpVsA0acB0YT7ddnDLWJH6AvqcKY-jHiCkwaj-jQ4xbrBukDj2q0FlDQwsmLpVR2mG38NgMaMKkzsmJht7jxSHPyefjw8fqOXl9e3pZ3b8mKr4REi1ByroAZHUuaiiWKhc6lwDABStLzVCUWsYW00qxmnFALJnggiMKKCSfk-tp78bZ7xF9qIbO7-8Hg3b0VZbnRcYjX0b0ZkKVs9471NXGdQO4XZWyau98tXe-Ojgf8asJt-Pmf_IX3feKwA</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Mimae, Takahiro</creator><creator>Miyata, Yoshihiro</creator><creator>Yoshimura, Kenichi</creator><creator>Tsutani, Yasuhiro</creator><creator>Imai, Kentaro</creator><creator>Ito, Hiroyuki</creator><creator>Nakayama, Haruhiko</creator><creator>Ikeda, Norihiko</creator><creator>Okada, Morihito</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9993-8928</orcidid></search><sort><creationdate>20211001</creationdate><title>Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy</title><author>Mimae, Takahiro ; Miyata, Yoshihiro ; Yoshimura, Kenichi ; Tsutani, Yasuhiro ; Imai, Kentaro ; Ito, Hiroyuki ; Nakayama, Haruhiko ; Ikeda, Norihiko ; Okada, Morihito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-fbabbd7ae0d56da74c56f5baaa36088f0e68fb6f50fcc0d03aee806363ee6a7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mimae, Takahiro</creatorcontrib><creatorcontrib>Miyata, Yoshihiro</creatorcontrib><creatorcontrib>Yoshimura, Kenichi</creatorcontrib><creatorcontrib>Tsutani, Yasuhiro</creatorcontrib><creatorcontrib>Imai, Kentaro</creatorcontrib><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Nakayama, Haruhiko</creatorcontrib><creatorcontrib>Ikeda, Norihiko</creatorcontrib><creatorcontrib>Okada, Morihito</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mimae, Takahiro</au><au>Miyata, Yoshihiro</au><au>Yoshimura, Kenichi</au><au>Tsutani, Yasuhiro</au><au>Imai, Kentaro</au><au>Ito, Hiroyuki</au><au>Nakayama, Haruhiko</au><au>Ikeda, Norihiko</au><au>Okada, Morihito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy</atitle><jtitle>Japanese journal of clinical oncology</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>51</volume><issue>10</issue><spage>1561</spage><epage>1569</epage><pages>1561-1569</pages><issn>1465-3621</issn><eissn>1465-3621</eissn><abstract>Abstract Objective We aimed to determine the influences of surgical procedures on the postoperative death of octogenarians with clinical Stage IA non-small cell lung cancer excluding cT1mi. Methods We compared overall survival and the cumulative incidence of death due to all and other causes among 1 130 279, and 191 consecutive patients aged ≤79 and ≥80 years after lobectomy, segmentectomy and wedge resection at three institutions. Death due to other causes was defined as death due to any cause except non-small cell lung cancer. Results The median followup was 53 months. The 5-year overall survival rates for patients aged ≥ 80 and ≤ 79 years after lobectomy, segmentectomy and wedge resection were respectively, 78.0% (95% confidence interval, 63.8%–87.2%) versus 91.2% (95% confidence interval, 89.0%–92.9%), 68.1% (95% confidence interval, 45.2%–83.1%) versus 90.0% (95% confidence interval, 84.6%–93.5%), and 62.7% (95% confidence interval, 44.0–76.7%) versus 84.4% (95% confidence interval, 76.3%–89.9%) (P &lt; 0.01 for all). The cumulative incidence of death due to other causes after wedge resection was similar between patients aged ≥ 80 and ≤ 79 years (P = 0.45), but significantly higher in those aged ≥ 80, than ≤ 79 years after lobectomy or segmentectomy (P = 0.00015 and 0.00091, respectively). Conclusions The influence of wedge resection on death due to other causes was lower than that of lobectomy or segmentectomy in patients with non-small cell lung cancer aged ≥ 80 years. Wedge resection might be a useful option for octogenarians even if they can tolerate lobectomy/segmentectomy to avoid postoperative death due to causes other than non-small cell lung cancer. This study provides useful information with which to determine optimal surgical procedures for patients aged ≥ 80 years. Wedge resection is useful for octogenarians with non-small cell lung cancer, especially considering postoperative death due to other causes.</abstract><pub>Oxford University Press</pub><doi>10.1093/jjco/hyab122</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9993-8928</orcidid><oa>free_for_read</oa></addata></record>
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title Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy
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