Effect of a very low-carbohydrate ketogenic diet vs recommended diets in patients with type 2 diabetes: a meta-analysis

Abstract Context There is renewed interest in using very low-carbohydrate ketogenic (VLCK) diets to manage diabetes. Many clinical trials have been published, often with mixed results. Objective This meta-analysis compares the effect of a VLCK diet on glycemic control, body weight, lipid profile, me...

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Bibliographic Details
Published in:Nutrition reviews 2022-02, Vol.80 (3), p.488-502
Main Authors: Rafiullah, Mohamed, Musambil, Mohthash, David, Satish Kumar
Format: Article
Language:English
Subjects:
Adult
Diabetes Mellitus, Type 2
Diet, Carbohydrate-Restricted
Diet, Ketogenic
Glycated Hemoglobin A
Humans
Weight Loss
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Summary:Abstract Context There is renewed interest in using very low-carbohydrate ketogenic (VLCK) diets to manage diabetes. Many clinical trials have been published, often with mixed results. Objective This meta-analysis compares the effect of a VLCK diet on glycemic control, body weight, lipid profile, medication use, and dropouts with that of recommended diets for 12 weeks or longer in people with type 2 diabetes. Data Sources Ovid MEDLINE, Ovid Embase, CENTRAL, and CINAHL databases were searched (January 1980 through September 2019). Study Selection Two authors independently reviewed search results to select randomized controlled trials (RCTs) comparing a VLCK diet (carbohydrate intake
ISSN:0029-6643
1753-4887
DOI:10.1093/nutrit/nuab040