Altered cardiometabolic profile in girls with central precocious puberty and adipokines: A propensity score matching analysis

•Patients with CPP have an increased cardiovascular risk in adulthood.•Since the diagnosis of CPP, the girls have an altered cardiometabolic profile.•CPP girls at diagnosis have higher free leptin levels and hypertriglyceridemia.•In CPP, the altered cardiometabolic profile is independent of BMI. To...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2021-12, Vol.148, p.155660-155660, Article 155660
Main Authors: Zurita-Cruz, Jessie N., Villasís-Keever, Miguel A., Manuel-Apolinar, Leticia, Damasio-Santana, Leticia, Gutierrez-Gonzalez, Alejandro, Wakida-Kusunoki, Guillermo, Padilla-Rojas, Michel, Maldonado-Rivera, Cesar, Garrido-Magaña, Eulalia, Rivera-Hernández, Aleida de J., Nishimura-Meguro, Elisa
Format: Article
Language:English
Subjects:
Adipokines - blood
Adiponectin
Cardiometabolic factors
Central precocious puberty
Child
Female
Humans
Leptin
Lipids - blood
Myocardium - metabolism
Obesity
Propensity Score
Puberty, Precocious - blood
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Summary:•Patients with CPP have an increased cardiovascular risk in adulthood.•Since the diagnosis of CPP, the girls have an altered cardiometabolic profile.•CPP girls at diagnosis have higher free leptin levels and hypertriglyceridemia.•In CPP, the altered cardiometabolic profile is independent of BMI. To compare cardiometabolic factors and adipokines between patients with recently diagnosed CPP and controls without CPP, paired by BMI Z scores (BMIz) and classified into girls with adequate nutritional status and girls who are overweight or obese. This cross-sectional study was performed from January 2012 to May 2015 at two tertiary care pediatric centers in Mexico City. We included female patients with idiopathic CPP without other chronic pathology and healthy controls. Patients were divided into groups, BMI 
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2021.155660