Urine-based regenerative RNA biomarkers for urinary bladder wound healing

This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcriptio...

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Bibliographic Details
Published in:Regenerative medicine 2021-08, Vol.16 (8), p.709-718
Main Authors: Liu, Chanzhen, Zhou, Juan, Li, You, Lu, Yulei, Lu, Haoyuan, Wei, Wei, Wu, Mingsong, Yi, Xianlin
Format: Article
Language:English
Subjects:
bladder injury
cholinergic receptor
regeneration
stem cell
urine
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Summary:This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected. HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing. The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.
ISSN:1746-0751
1746-076X
DOI:10.2217/rme-2021-0057