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Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis
Background Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surger...
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| Published in: | Obesity surgery 2021-11, Vol.31 (11), p.4761-4766 |
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| container_title | Obesity surgery |
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| creator | da Costa Leite Junior, Gerson Lacerda, Mille Dantas Alencar, Thalita Arraes Lopes Barreira Café, Marcio Giuffrida, Fernando M. A. |
| description | Background
Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surgery.
Methods
Seventy-nine individuals undergoing gastric bypass have been studied at 4 time points (preoperative and 1, 3, and 6 months after surgery). Weight, body mass index (BMI), iron, ferritin, vitamin B12, folate, hemoglobin, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and use of iron replacement were recorded
.
Results
Forty-two individuals (53%) had moderate/severe steatosis assessed by ultrasound. No differences were seen in iron profile and replacement therapy features compared to individuals with no/mild steatosis both in the preoperative and postoperative periods. Mixed model analysis showed ferritin levels to be higher in the moderate/severe steatosis group than in no/mild steatosis at the 6th month (139 ± 131 vs. 60.9 ± 49.8,
p
|
| doi_str_mv | 10.1007/s11695-021-05629-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2557548591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557548591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-59fbd7f4f6a5d081cb3ac620c2d55476ca51378e6a01d23c3e664ec333f8e4763</originalsourceid><addsrcrecordid>eNp9kM1KAzEURoMoWKsv4Crgxs1ofiaZZNkWawsFBRWXIc1kbEo7qUlG2rc3bQXBhat74Tvf5XIAuMboDiNU3UeMuWQFIrhAjBNZbE9AD1dIFKgk4hT0kOSoEJLQc3AR4xJlkhPSA_XQLvSX8wH6Bk6Db6Fuazi2IbjkWjhokg1wqIPTKTgDX7rwYcMO5uhZJ2fbFOG7S4tDa7_4LsGJ3eQsw8nq5KOLl-Cs0ator35mH7yNH15Hk2L29DgdDWaFoYykgslmXldN2XDNaiSwmVNtOEGG1IyVFTeaYVoJyzXCNaGGWs5LayiljbA5p31we7y7Cf6zszGptYvGrla6tb6LijBWsVIwiTN68wdd-i60-btMVUJiJkuRKXKkTPAxBtuoTXBrHXYKI7UXr47iVdapDuLVNpfosRQz3GZdv6f_aX0DfEWGVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2578915948</pqid></control><display><type>article</type><title>Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis</title><source>Springer Nature</source><creator>da Costa Leite Junior, Gerson ; Lacerda, Mille Dantas ; Alencar, Thalita Arraes Lopes Barreira ; Café, Marcio ; Giuffrida, Fernando M. A.</creator><creatorcontrib>da Costa Leite Junior, Gerson ; Lacerda, Mille Dantas ; Alencar, Thalita Arraes Lopes Barreira ; Café, Marcio ; Giuffrida, Fernando M. A.</creatorcontrib><description><![CDATA[Background
Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surgery.
Methods
Seventy-nine individuals undergoing gastric bypass have been studied at 4 time points (preoperative and 1, 3, and 6 months after surgery). Weight, body mass index (BMI), iron, ferritin, vitamin B12, folate, hemoglobin, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and use of iron replacement were recorded
.
Results
Forty-two individuals (53%) had moderate/severe steatosis assessed by ultrasound. No differences were seen in iron profile and replacement therapy features compared to individuals with no/mild steatosis both in the preoperative and postoperative periods. Mixed model analysis showed ferritin levels to be higher in the moderate/severe steatosis group than in no/mild steatosis at the 6th month (139 ± 131 vs. 60.9 ± 49.8,
p
< 0.05). Values in both groups were lower than baseline, with
p
< 0.0001. The same was observed with serum iron (92.1 ± 39.6 moderate/severe steatosis vs. 68.6 ± 33.4 no/mild steatosis,
p
< 0.001;
p
from baseline < 0.01 for both). GGT was higher in moderate/severe steatosis in the 3rd month (38.8 ± 40.5 vs. 28.8 ± 20.8,
p
< 0.05;
p
from baseline < 0.0001 for both).
Conclusions
Ferritin levels were consistently higher in individuals with steatosis in the follow-up of bariatric surgery, but no apparent implication on the diagnosis of iron deficiency and in the prescription of replacement therapy was demonstrated at 6 months of follow-up. Longer studies are probably necessary to investigate this matter.
Graphical abstract]]></description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-021-05629-x</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anemia ; Gastrointestinal surgery ; Iron ; Liver diseases ; Medicine ; Medicine & Public Health ; Obesity ; Original Contributions ; Surgery</subject><ispartof>Obesity surgery, 2021-11, Vol.31 (11), p.4761-4766</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-59fbd7f4f6a5d081cb3ac620c2d55476ca51378e6a01d23c3e664ec333f8e4763</citedby><cites>FETCH-LOGICAL-c352t-59fbd7f4f6a5d081cb3ac620c2d55476ca51378e6a01d23c3e664ec333f8e4763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids></links><search><creatorcontrib>da Costa Leite Junior, Gerson</creatorcontrib><creatorcontrib>Lacerda, Mille Dantas</creatorcontrib><creatorcontrib>Alencar, Thalita Arraes Lopes Barreira</creatorcontrib><creatorcontrib>Café, Marcio</creatorcontrib><creatorcontrib>Giuffrida, Fernando M. A.</creatorcontrib><title>Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><description><![CDATA[Background
Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surgery.
Methods
Seventy-nine individuals undergoing gastric bypass have been studied at 4 time points (preoperative and 1, 3, and 6 months after surgery). Weight, body mass index (BMI), iron, ferritin, vitamin B12, folate, hemoglobin, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and use of iron replacement were recorded
.
Results
Forty-two individuals (53%) had moderate/severe steatosis assessed by ultrasound. No differences were seen in iron profile and replacement therapy features compared to individuals with no/mild steatosis both in the preoperative and postoperative periods. Mixed model analysis showed ferritin levels to be higher in the moderate/severe steatosis group than in no/mild steatosis at the 6th month (139 ± 131 vs. 60.9 ± 49.8,
p
< 0.05). Values in both groups were lower than baseline, with
p
< 0.0001. The same was observed with serum iron (92.1 ± 39.6 moderate/severe steatosis vs. 68.6 ± 33.4 no/mild steatosis,
p
< 0.001;
p
from baseline < 0.01 for both). GGT was higher in moderate/severe steatosis in the 3rd month (38.8 ± 40.5 vs. 28.8 ± 20.8,
p
< 0.05;
p
from baseline < 0.0001 for both).
Conclusions
Ferritin levels were consistently higher in individuals with steatosis in the follow-up of bariatric surgery, but no apparent implication on the diagnosis of iron deficiency and in the prescription of replacement therapy was demonstrated at 6 months of follow-up. Longer studies are probably necessary to investigate this matter.
Graphical abstract]]></description><subject>Anemia</subject><subject>Gastrointestinal surgery</subject><subject>Iron</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Original Contributions</subject><subject>Surgery</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KAzEURoMoWKsv4Crgxs1ofiaZZNkWawsFBRWXIc1kbEo7qUlG2rc3bQXBhat74Tvf5XIAuMboDiNU3UeMuWQFIrhAjBNZbE9AD1dIFKgk4hT0kOSoEJLQc3AR4xJlkhPSA_XQLvSX8wH6Bk6Db6Fuazi2IbjkWjhokg1wqIPTKTgDX7rwYcMO5uhZJ2fbFOG7S4tDa7_4LsGJ3eQsw8nq5KOLl-Cs0ator35mH7yNH15Hk2L29DgdDWaFoYykgslmXldN2XDNaiSwmVNtOEGG1IyVFTeaYVoJyzXCNaGGWs5LayiljbA5p31we7y7Cf6zszGptYvGrla6tb6LijBWsVIwiTN68wdd-i60-btMVUJiJkuRKXKkTPAxBtuoTXBrHXYKI7UXr47iVdapDuLVNpfosRQz3GZdv6f_aX0DfEWGVg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>da Costa Leite Junior, Gerson</creator><creator>Lacerda, Mille Dantas</creator><creator>Alencar, Thalita Arraes Lopes Barreira</creator><creator>Café, Marcio</creator><creator>Giuffrida, Fernando M. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis</title><author>da Costa Leite Junior, Gerson ; Lacerda, Mille Dantas ; Alencar, Thalita Arraes Lopes Barreira ; Café, Marcio ; Giuffrida, Fernando M. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-59fbd7f4f6a5d081cb3ac620c2d55476ca51378e6a01d23c3e664ec333f8e4763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anemia</topic><topic>Gastrointestinal surgery</topic><topic>Iron</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Original Contributions</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Costa Leite Junior, Gerson</creatorcontrib><creatorcontrib>Lacerda, Mille Dantas</creatorcontrib><creatorcontrib>Alencar, Thalita Arraes Lopes Barreira</creatorcontrib><creatorcontrib>Café, Marcio</creatorcontrib><creatorcontrib>Giuffrida, Fernando M. A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Costa Leite Junior, Gerson</au><au>Lacerda, Mille Dantas</au><au>Alencar, Thalita Arraes Lopes Barreira</au><au>Café, Marcio</au><au>Giuffrida, Fernando M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><date>2021-11</date><risdate>2021</risdate><volume>31</volume><issue>11</issue><spage>4761</spage><epage>4766</epage><pages>4761-4766</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract><![CDATA[Background
Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surgery.
Methods
Seventy-nine individuals undergoing gastric bypass have been studied at 4 time points (preoperative and 1, 3, and 6 months after surgery). Weight, body mass index (BMI), iron, ferritin, vitamin B12, folate, hemoglobin, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and use of iron replacement were recorded
.
Results
Forty-two individuals (53%) had moderate/severe steatosis assessed by ultrasound. No differences were seen in iron profile and replacement therapy features compared to individuals with no/mild steatosis both in the preoperative and postoperative periods. Mixed model analysis showed ferritin levels to be higher in the moderate/severe steatosis group than in no/mild steatosis at the 6th month (139 ± 131 vs. 60.9 ± 49.8,
p
< 0.05). Values in both groups were lower than baseline, with
p
< 0.0001. The same was observed with serum iron (92.1 ± 39.6 moderate/severe steatosis vs. 68.6 ± 33.4 no/mild steatosis,
p
< 0.001;
p
from baseline < 0.01 for both). GGT was higher in moderate/severe steatosis in the 3rd month (38.8 ± 40.5 vs. 28.8 ± 20.8,
p
< 0.05;
p
from baseline < 0.0001 for both).
Conclusions
Ferritin levels were consistently higher in individuals with steatosis in the follow-up of bariatric surgery, but no apparent implication on the diagnosis of iron deficiency and in the prescription of replacement therapy was demonstrated at 6 months of follow-up. Longer studies are probably necessary to investigate this matter.
Graphical abstract]]></abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11695-021-05629-x</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Anemia Gastrointestinal surgery Iron Liver diseases Medicine Medicine & Public Health Obesity Original Contributions Surgery |
| title | Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis |
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