Femoral nerve neuromonitoring for lateral lumbar interbody fusion surgery

• Published in: The spine journal 2022-02, Vol.22 (2), p.296-304
• Main Authors: Silverstein, Justin W., Block, Jon, Smith, Michael L., Bomback, David A., Sanderson, Scott, Paul, Justin, Ball, Hieu, Ellis, Jason A., Goldstein, Matthew, Kramer, David L., Arutyunyan, Grigoriy, Marcus, Joshua, Mermelstein, Sara, Slosar, Paul, Goldthwaite, Noel, Lee, Sun Ik, Reynolds, James, Riordan, Margaret, Pirnia, Nick, Kunwar, Sandeep, Abbi, Gaurav, Bizzini, Bruce, Gupta, Sarita, Porter, Dorothy, Mermelstein, Laurence E.
• Format: Article
• Language: English
• Subjects: Evoked Potentials, Motor - physiology; Femoral nerve; Femoral Nerve - injuries; Humans; Lumbar lateral interbody fusion; Lumbar Vertebrae - surgery; Motor evoked potentials; Nerve injury; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Quadriceps; Retrospective Studies; Saphenous nerve; Somatosensory evoked potentials; Spinal Fusion - adverse effects; Spinal Fusion - methods
• ISSN: 1529-9430; 1878-1632
• DOI: 10.1016/j.spinee.2021.07.017

The transpsoas lateral lumbar interbody fusion (LLIF) technique is an effective alternative to traditional anterior and posterior approaches to the lumbar spine; however, nerve injuries are the most reported postoperative complication. Commonly used strategies to avoid nerve injury (eg, limiting retraction duration) have not been effective in detecting or preventing femoral nerve injuries. To evaluate the efficacy of emerging intraoperative femoral nerve monitoring techniques and the importance of employing prompt surgical countermeasures when degraded femoral nerve function is detected. We present the results from a retrospective analysis of a multi-center study conducted over the course of 3 years. One hundred and seventy-two lateral lumbar interbody fusion procedures were reviewed. Intraoperative femoral nerve monitoring data was correlated to immediate postoperative neurologic examinations. Femoral nerve evoked potentials (FNEP) including saphenous nerve somatosensory evoked potentials (snSSEP) and motor evoked potentials with quadriceps recordings were used to detect evidence of degraded femoral nerve function during the time of surgical retraction. In 89% (n=153) of the surgeries, there were no surgeon alerts as the FNEP response amplitudes remained relatively unchanged throughout the surgery (negative group). The positive group included 11% of the cases (n=19) where the surgeon was alerted to a deterioration of the FNEP amplitudes during surgical retraction. Prompt surgical countermeasures to an FNEP alert included loosening, adjusting, or removing surgical retraction, and/or requesting an increase in blood pressure from the anesthesiologist. All the cases where prompt surgical countermeasures were employed resulted in recovery of the degraded FNEP amplitudes and no postoperative femoral nerve injuries. In two cases, the surgeons were given verbal alerts of degraded FNEPs but did not employ prompt surgical countermeasures. In both cases, the degraded FNEP amplitudes did not recover by the time of surgical closure, and both patients exhibited postoperative signs of sensorimotor femoral nerve injury including anterior thigh numbness and weakened knee extension. Multimodal femoral nerve monitoring can provide surgeons with a timely alert to hyperacute femoral nerve conduction failure, enabling prompt surgical countermeasures to be employed that can mitigate or avoid femoral nerve injury. Our data also suggests that the common strategy of limiting retra