Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique featur...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2021-09, Vol.33 (38), p.e2102580-n/a
Main Authors: Li, Zhaoting, Wang, Yixin, Liu, Jun, Rawding, Piper, Bu, Jiyoon, Hong, Seungpyo, Hu, Quanyin
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteria - genetics
Biocompatibility
bioengineering
Biomedical materials
Biotechnology
chemical engineering
Diagnosis
Drug Delivery Systems
Humans
Infectious diseases
Microorganisms
Neoplasms - diagnosis
Neoplasms - therapy
therapy
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Summary:Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria‐based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria‐based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy. Bacteria‐based delivery systems are versatile platforms developed for diagnosis and therapy. The fundamentals and design principles of chemically and biologically engineered bacteria delivery systems are summarized, and recent advances of their application in emerging diagnosis and advanced therapy are highlighted, including microbial modulation and clinical translation, which have offered tremendous promise for various disease treatments.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.202102580