Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction

Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 478...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2021-10, Vol.156, p.9-15
Main Authors: Wang, Xu, Montero-Cabezas, Jose M, Mandurino-Mirizzi, Alessandro, Hirasawa, Kensuke, Ajmone Marsan, Nina, Knuuti, Juhani, Bax, Jeroen J, Delgado, Victoria
Format: Article
Language:English
Subjects:
Angiography
Arteries
Blood clots
Cardiovascular disease
Cerebral infarction
Coronary artery
Coronary vessels
Diabetes
Heart attacks
Heart surgery
Implants
Information systems
Males
Medical imaging
Myocardial infarction
Pathogenesis
Phenotypes
Regression analysis
Risk analysis
Risk factors
Segments
Stents
Stroke
Surgical implants
Survival analysis
Thrombosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683
cites cdi_FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683
container_end_page 15
container_issue
container_start_page 9
container_title The American journal of cardiology
container_volume 156
creator Wang, Xu
Montero-Cabezas, Jose M
Mandurino-Mirizzi, Alessandro
Hirasawa, Kensuke
Ajmone Marsan, Nina
Knuuti, Juhani
Bax, Jeroen J
Delgado, Victoria
description Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 4788 patients presenting with AMI referred for coronary angiography the presence of CAE (defined as dilation of a coronary segment with a diameter ≥1.5 times of the adjacent normal segment) was confirmed in 174 (3.6%) patients (age 62 ± 12 years; 81% male), and was present in the culprit vessel in 79.9%. Multivessel CAE was frequent (67%). CAE patients were more frequently male, had high thrombus burden and were treated more often with thrombectomy and less often was stent implantation. Markis I was the most frequent angiographic phenotype (43%). During a median follow-up of 4 years (1-7), 1243 patients (26%) experienced a major adverse cardiovascular event (MACE): 282 (6%) died from a cardiac cause, 358 (8%) had a myocardial infarction, 945 (20%) underwent coronary revascularization and 58 (1%) presented with a stroke. Patients with CAE showed higher rates of MACE as compared to those without CAE (36.8% versus 25.6%; p
doi_str_mv 10.1016/j.amjcard.2021.06.037
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2558091764</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914921006196</els_id><sourcerecordid>2568243481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683</originalsourceid><addsrcrecordid>eNqFkU9r3DAQxUVpoNu0H6Eg6KUXuxrZ-ncqy5ImgS3JIT0LWdamMraUSvKW_fbVsjn10tMw8HuPmfcQ-gSkBQL869SaZbImjS0lFFrCW9KJN2gDUqgGFHRv0YYQQhsFvXqH3uc81RWA8Q06PiZ3NLML1mETRryP4bkpLi34YS02Li7jeMCPpngXSsZ_fPmFdzHFYNIJb1MlT_jGFpO9wdUqV8qH5wu3tWtx-Mcpnm_zZsb34WCSLT6GD-jqYObsPr7Oa_Tz-83T7q7ZP9ze77b7xvYgStN14AAG5SwdpBTWSBBMyQGUECPvHe0kF2QgQpmBcjZQ4IoBYYQzwjiX3TX6cvF9SfH36nLRi8_WzbMJLq5ZU8YkUSB4X9HP_6BTXFOo11WKS9p3vYRKsQtlU8w5uYN-SX6pYWgg-tyGnvRrG_rchiZc1zaq7ttF5-q3R--SztafUx99crboMfr_OPwFVKqUqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2568243481</pqid></control><display><type>article</type><title>Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction</title><source>ScienceDirect Freedom Collection</source><creator>Wang, Xu ; Montero-Cabezas, Jose M ; Mandurino-Mirizzi, Alessandro ; Hirasawa, Kensuke ; Ajmone Marsan, Nina ; Knuuti, Juhani ; Bax, Jeroen J ; Delgado, Victoria</creator><creatorcontrib>Wang, Xu ; Montero-Cabezas, Jose M ; Mandurino-Mirizzi, Alessandro ; Hirasawa, Kensuke ; Ajmone Marsan, Nina ; Knuuti, Juhani ; Bax, Jeroen J ; Delgado, Victoria</creatorcontrib><description>Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 4788 patients presenting with AMI referred for coronary angiography the presence of CAE (defined as dilation of a coronary segment with a diameter ≥1.5 times of the adjacent normal segment) was confirmed in 174 (3.6%) patients (age 62 ± 12 years; 81% male), and was present in the culprit vessel in 79.9%. Multivessel CAE was frequent (67%). CAE patients were more frequently male, had high thrombus burden and were treated more often with thrombectomy and less often was stent implantation. Markis I was the most frequent angiographic phenotype (43%). During a median follow-up of 4 years (1-7), 1243 patients (26%) experienced a major adverse cardiovascular event (MACE): 282 (6%) died from a cardiac cause, 358 (8%) had a myocardial infarction, 945 (20%) underwent coronary revascularization and 58 (1%) presented with a stroke. Patients with CAE showed higher rates of MACE as compared to those without CAE (36.8% versus 25.6%; p &lt;0.001). On multivariable analysis, CAE was associated with MACE (HR 1.597; 95% CI 1.238-2.060; p &lt;0.001) after adjusting for risk factors, type of AMI and number of narrowed coronary arteries. In conclusion, the prevalence of CAE in patients presenting with AMI is relatively low but was independently associated with an increased risk of MACE at follow-up.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2021.06.037</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Angiography ; Arteries ; Blood clots ; Cardiovascular disease ; Cerebral infarction ; Coronary artery ; Coronary vessels ; Diabetes ; Heart attacks ; Heart surgery ; Implants ; Information systems ; Males ; Medical imaging ; Myocardial infarction ; Pathogenesis ; Phenotypes ; Regression analysis ; Risk analysis ; Risk factors ; Segments ; Stents ; Stroke ; Surgical implants ; Survival analysis ; Thrombosis</subject><ispartof>The American journal of cardiology, 2021-10, Vol.156, p.9-15</ispartof><rights>2021 The Author(s)</rights><rights>2021. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683</citedby><cites>FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Xu</creatorcontrib><creatorcontrib>Montero-Cabezas, Jose M</creatorcontrib><creatorcontrib>Mandurino-Mirizzi, Alessandro</creatorcontrib><creatorcontrib>Hirasawa, Kensuke</creatorcontrib><creatorcontrib>Ajmone Marsan, Nina</creatorcontrib><creatorcontrib>Knuuti, Juhani</creatorcontrib><creatorcontrib>Bax, Jeroen J</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><title>Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction</title><title>The American journal of cardiology</title><description>Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 4788 patients presenting with AMI referred for coronary angiography the presence of CAE (defined as dilation of a coronary segment with a diameter ≥1.5 times of the adjacent normal segment) was confirmed in 174 (3.6%) patients (age 62 ± 12 years; 81% male), and was present in the culprit vessel in 79.9%. Multivessel CAE was frequent (67%). CAE patients were more frequently male, had high thrombus burden and were treated more often with thrombectomy and less often was stent implantation. Markis I was the most frequent angiographic phenotype (43%). During a median follow-up of 4 years (1-7), 1243 patients (26%) experienced a major adverse cardiovascular event (MACE): 282 (6%) died from a cardiac cause, 358 (8%) had a myocardial infarction, 945 (20%) underwent coronary revascularization and 58 (1%) presented with a stroke. Patients with CAE showed higher rates of MACE as compared to those without CAE (36.8% versus 25.6%; p &lt;0.001). On multivariable analysis, CAE was associated with MACE (HR 1.597; 95% CI 1.238-2.060; p &lt;0.001) after adjusting for risk factors, type of AMI and number of narrowed coronary arteries. In conclusion, the prevalence of CAE in patients presenting with AMI is relatively low but was independently associated with an increased risk of MACE at follow-up.</description><subject>Angiography</subject><subject>Arteries</subject><subject>Blood clots</subject><subject>Cardiovascular disease</subject><subject>Cerebral infarction</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Heart attacks</subject><subject>Heart surgery</subject><subject>Implants</subject><subject>Information systems</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Myocardial infarction</subject><subject>Pathogenesis</subject><subject>Phenotypes</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Segments</subject><subject>Stents</subject><subject>Stroke</subject><subject>Surgical implants</subject><subject>Survival analysis</subject><subject>Thrombosis</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkU9r3DAQxUVpoNu0H6Eg6KUXuxrZ-ncqy5ImgS3JIT0LWdamMraUSvKW_fbVsjn10tMw8HuPmfcQ-gSkBQL869SaZbImjS0lFFrCW9KJN2gDUqgGFHRv0YYQQhsFvXqH3uc81RWA8Q06PiZ3NLML1mETRryP4bkpLi34YS02Li7jeMCPpngXSsZ_fPmFdzHFYNIJb1MlT_jGFpO9wdUqV8qH5wu3tWtx-Mcpnm_zZsb34WCSLT6GD-jqYObsPr7Oa_Tz-83T7q7ZP9ze77b7xvYgStN14AAG5SwdpBTWSBBMyQGUECPvHe0kF2QgQpmBcjZQ4IoBYYQzwjiX3TX6cvF9SfH36nLRi8_WzbMJLq5ZU8YkUSB4X9HP_6BTXFOo11WKS9p3vYRKsQtlU8w5uYN-SX6pYWgg-tyGnvRrG_rchiZc1zaq7ttF5-q3R--SztafUx99crboMfr_OPwFVKqUqw</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Wang, Xu</creator><creator>Montero-Cabezas, Jose M</creator><creator>Mandurino-Mirizzi, Alessandro</creator><creator>Hirasawa, Kensuke</creator><creator>Ajmone Marsan, Nina</creator><creator>Knuuti, Juhani</creator><creator>Bax, Jeroen J</creator><creator>Delgado, Victoria</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20211001</creationdate><title>Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction</title><author>Wang, Xu ; Montero-Cabezas, Jose M ; Mandurino-Mirizzi, Alessandro ; Hirasawa, Kensuke ; Ajmone Marsan, Nina ; Knuuti, Juhani ; Bax, Jeroen J ; Delgado, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiography</topic><topic>Arteries</topic><topic>Blood clots</topic><topic>Cardiovascular disease</topic><topic>Cerebral infarction</topic><topic>Coronary artery</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Heart attacks</topic><topic>Heart surgery</topic><topic>Implants</topic><topic>Information systems</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Myocardial infarction</topic><topic>Pathogenesis</topic><topic>Phenotypes</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Segments</topic><topic>Stents</topic><topic>Stroke</topic><topic>Surgical implants</topic><topic>Survival analysis</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xu</creatorcontrib><creatorcontrib>Montero-Cabezas, Jose M</creatorcontrib><creatorcontrib>Mandurino-Mirizzi, Alessandro</creatorcontrib><creatorcontrib>Hirasawa, Kensuke</creatorcontrib><creatorcontrib>Ajmone Marsan, Nina</creatorcontrib><creatorcontrib>Knuuti, Juhani</creatorcontrib><creatorcontrib>Bax, Jeroen J</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database (ProQuest)</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xu</au><au>Montero-Cabezas, Jose M</au><au>Mandurino-Mirizzi, Alessandro</au><au>Hirasawa, Kensuke</au><au>Ajmone Marsan, Nina</au><au>Knuuti, Juhani</au><au>Bax, Jeroen J</au><au>Delgado, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction</atitle><jtitle>The American journal of cardiology</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>156</volume><spage>9</spage><epage>15</epage><pages>9-15</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 4788 patients presenting with AMI referred for coronary angiography the presence of CAE (defined as dilation of a coronary segment with a diameter ≥1.5 times of the adjacent normal segment) was confirmed in 174 (3.6%) patients (age 62 ± 12 years; 81% male), and was present in the culprit vessel in 79.9%. Multivessel CAE was frequent (67%). CAE patients were more frequently male, had high thrombus burden and were treated more often with thrombectomy and less often was stent implantation. Markis I was the most frequent angiographic phenotype (43%). During a median follow-up of 4 years (1-7), 1243 patients (26%) experienced a major adverse cardiovascular event (MACE): 282 (6%) died from a cardiac cause, 358 (8%) had a myocardial infarction, 945 (20%) underwent coronary revascularization and 58 (1%) presented with a stroke. Patients with CAE showed higher rates of MACE as compared to those without CAE (36.8% versus 25.6%; p &lt;0.001). On multivariable analysis, CAE was associated with MACE (HR 1.597; 95% CI 1.238-2.060; p &lt;0.001) after adjusting for risk factors, type of AMI and number of narrowed coronary arteries. In conclusion, the prevalence of CAE in patients presenting with AMI is relatively low but was independently associated with an increased risk of MACE at follow-up.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.amjcard.2021.06.037</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2021-10, Vol.156, p.9-15
issn 0002-9149
1879-1913
language eng
recordid cdi_proquest_miscellaneous_2558091764
source ScienceDirect Freedom Collection
subjects Angiography
Arteries
Blood clots
Cardiovascular disease
Cerebral infarction
Coronary artery
Coronary vessels
Diabetes
Heart attacks
Heart surgery
Implants
Information systems
Males
Medical imaging
Myocardial infarction
Pathogenesis
Phenotypes
Regression analysis
Risk analysis
Risk factors
Segments
Stents
Stroke
Surgical implants
Survival analysis
Thrombosis
title Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A50%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20Long-term%20Outcomes%20of%20Patients%20with%20Coronary%20Artery%20Ectasia%20Presenting%20with%20Acute%20Myocardial%20Infarction&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Wang,%20Xu&rft.date=2021-10-01&rft.volume=156&rft.spage=9&rft.epage=15&rft.pages=9-15&rft.issn=0002-9149&rft.eissn=1879-1913&rft_id=info:doi/10.1016/j.amjcard.2021.06.037&rft_dat=%3Cproquest_cross%3E2568243481%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c417t-331e11b9ec2b887ca817598b1977d64e238670b079ab265b21695105065056683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2568243481&rft_id=info:pmid/&rfr_iscdi=true