Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma

Background Serum creatine kinase level has been reported to be a prognostic indicator in breast or lung cancers but no reports have been in esophageal cancer. We analyzed the prognostic significance of preoperative serum creatine kinase level in patients with esophageal carcinoma. Methods We evaluat...

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Bibliographic Details
Published in:Esophagus : official journal of the Japan Esophageal Society 2022, Vol.19 (1), p.105-112
Main Authors: Murayama, Kenji, Suzuki, Takashi, Yajima, Satoshi, Oshima, Yoko, Nanami, Tatsuki, Shiratori, Fumiaki, Shimada, Hideaki
Format: Article
Language:English
Subjects:
Age
Body mass index
Cancer surgery
Cell cycle
Creatine Kinase
Creatinine
Drug dosages
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Squamous Cell Carcinoma - surgery
Female
Gastroenterology
Gender
Humans
Kinases
Male
Males
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Original Article
Prognosis
Regression analysis
Retrospective Studies
Squamous cell carcinoma
Surgical Oncology
Thoracic Surgery
Values
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Summary:Background Serum creatine kinase level has been reported to be a prognostic indicator in breast or lung cancers but no reports have been in esophageal cancer. We analyzed the prognostic significance of preoperative serum creatine kinase level in patients with esophageal carcinoma. Methods We evaluated the preoperative serum creatine kinase levels of 148 patients (118 male and 30 female) with esophageal squamous cell carcinoma. According to their median serum creatine kinase levels, we divided the patients into high and low serum creatine kinase groups. Univariate and multivariate analyses were used to evaluate the impact of serum creatine kinase level on the prognosis of the patients. Results The tumor depth ( P  
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-021-00866-6