Fibrinogen, fibrin degradation products and risk of sarcopenia

Increasing data suggests that chronic low-grade inflammation plays an important role on development of sarcopenia. The present study was designed to identify the association between fibrinogen, fibrin degradation products (FDP) and sarcopenia risk in hospitalized old patients. A total of 437 patient...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-08, Vol.40 (8), p.4830-4837
Main Authors: Chen, Jin-Liang, Chen, Dong-Mei, Luo, Cheng, Sun, Yue, Zhao, Yu-Xing, Huang, Chang-Quan, Zhao, Ke-Xiang, Xiao, Qian
Format: Article
Language:English
Subjects:
Aged
Body Composition
Cross-Sectional Studies
Elderly
Female
Fibrin degradation products
Fibrin Fibrinogen Degradation Products - metabolism
Fibrinogen
Fibrinogen - metabolism
Geriatric Assessment
Hand Strength
Humans
Inflammation
Inpatients - statistics & numerical data
Linear Models
Male
Middle Aged
Odds Ratio
Reference Values
Risk Factors
ROC Curve
Sarcopenia
Sarcopenia - blood
Sarcopenia - etiology
Walking Speed
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Summary:Increasing data suggests that chronic low-grade inflammation plays an important role on development of sarcopenia. The present study was designed to identify the association between fibrinogen, fibrin degradation products (FDP) and sarcopenia risk in hospitalized old patients. A total of 437 patients were enrolled in this cross-sectional study (148 with sarcopenia and 289 without sarcopenia). Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Body composition, grip strength and gait speed were performed to participants. Fibrinogen, FDP levels were measured. Logistic regression analyses were carried out to assess the association between fibrinogen and sarcopenia, between FDP and sarcopenia, respectively. Compared to non-sarcopenic patients, fibrinogen and FDP levels were found to be higher in the sarcopenic group (3.07 g/L vs 2.79 g/L, 1.75 μg/mL vs 1.00 μg/mL, respectively, p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2021.06.031