Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL

Background Cushing's syndrome (CS) is associated with skeletal muscle structural and functional impairment which may persist long‐term despite surgical removal of the source of cortisol excess. Prevalence of sarcopenia and its impact on Health‐Related‐Quality of Life (HRQoL) in ‘cured’ CS is no...

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Published in:Clinical endocrinology (Oxford) 2021-11, Vol.95 (5), p.735-743
Main Authors: Martel‐Duguech, Luciana, Alonso‐Jimenez, Alicia, Bascuñana, Helena, Díaz‐Manera, Jordi, Llauger, Jaume, Nuñez‐Peralta, Claudia, Montesinos, Paula, Webb, Susan M., Valassi, Elena
Format: Article
Language:English
Subjects:
Biomarkers
Body mass index
Cortisol
Creatinine
Cushing syndrome
Cushing's syndrome
Cystatin C
fatty infiltration
Gait
Magnetic resonance imaging
Menopause
muscle performance
Musculoskeletal system
Physical activity
Quality of life
Questionnaires
Remission
Remission (Medicine)
Sarcopenia
Skeletal muscle
Structure-function relationships
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Summary:Background Cushing's syndrome (CS) is associated with skeletal muscle structural and functional impairment which may persist long‐term despite surgical removal of the source of cortisol excess. Prevalence of sarcopenia and its impact on Health‐Related‐Quality of Life (HRQoL) in ‘cured’ CS is not known. There is a need to identify easy biomarkers to help the clinicians recognise patients at elevated risk of suffering sustained muscle function. Patients and Methods We studied 36 women with CS in remission, and 36 controls matched for age, body mass index, menopausal status, and level of physical activity. We analysed the skeletal muscle mass using dual‐energy X‐ray absorptiometry, muscle fat fraction using two‐point Dixon magnetic resonance imaging and muscle performance and strength using the following tests: hand grip strength, gait speed, timed up and go and 30‐s chair stand. We assessed HRQoL with the following questionnaires: SarQoL, CushingQoL, SF‐36. We calculated the sarcopenia index (SI; serum creatinine/serum cystatin C × 100). Results Prevalence of sarcopenia, according to the European Working Group on Sarcopenia in Older People (EWGSOP), was greater in CS as compared with controls (19% vs. 3%; p 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14568