Prognosis of anal canal adenocarcinoma versus lower rectal adenocarcinoma in Japan: a propensity score matching study

Purpose Anal canal adenocarcinoma (AC) is rare and its surgical outcomes and prognostic factors (PFs) are not well understood. The aim of this retrospective study was to identify the characteristics and PFs of AC, using population-based data in Japan. Methods Patients with AC ( n  = 390) or lower re...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2022-03, Vol.52 (3), p.420-430
Main Authors: Saiki, Yasumitsu, Yamada, Kazutaka, Tanaka, Masafumi, Fukunaga, Mitsuko, Irei, Yasue, Suzuki, Takafumi
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Anal Canal - pathology
Female
Humans
Japan - epidemiology
Medicine
Medicine & Public Health
Neoplasm Staging
Original Article
Prognosis
Propensity Score
Retrospective Studies
Surgery
Surgical Oncology
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Summary:Purpose Anal canal adenocarcinoma (AC) is rare and its surgical outcomes and prognostic factors (PFs) are not well understood. The aim of this retrospective study was to identify the characteristics and PFs of AC, using population-based data in Japan. Methods Patients with AC ( n  = 390) or lower rectal adenocarcinoma (LR) ( n  = 12,477) diagnosed between1991 and 2006 were enrolled in this study. We compared the clinical- and patient-related factors of the two diseases and then examined propensity score matching, overall survival (OS), and PFs. Results AC tended to develop more often in women and in patients of advanced age. Macroscopically, AC was of an unclassified type and microscopically, it was of high-grade histological types such as mucinous adenocarcinoma, poorly differentiated adenocarcinoma (por), or signet-ring cell carcinoma (sig), with a high frequency of inguinal node metastasis ( P  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-021-02350-1