Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies

Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a very poor prognosis. The standard treatment for newly diagnosed patients involves total tumor surgical resection (if possible), plus irradiation and adjuvant chemotherapy. Despite treatment, the prognosis is sti...

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Bibliographic Details
Published in:Biomaterials science 2021-09, Vol.9 (18), p.637-651
Main Authors: Alghamdi, Majed, Gumbleton, Mark, Newland, Ben
Format: Article
Language:English
Subjects:
Bioavailability
Biocompatibility
Biomedical materials
Blood-brain barrier
Brain cancer
Drug delivery systems
Hydrogels
Hypoxia
Prognosis
Surgical implants
Toxicity
Tumors
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Summary:Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a very poor prognosis. The standard treatment for newly diagnosed patients involves total tumor surgical resection (if possible), plus irradiation and adjuvant chemotherapy. Despite treatment, the prognosis is still poor, and the tumor often recurs within two centimeters of the original tumor. A promising approach to improving the efficacy of GBM therapeutics is to utilize biomaterials to deliver them locally at the tumor site. Local delivery to GBM offers several advantages over systemic administration, such as bypassing the blood-brain barrier and increasing the bioavailability of the therapeutic at the tumor site without causing systemic toxicity. Local delivery may also combat tumor recurrence by maintaining sufficient drug concentrations at and surrounding the original tumor area. Herein, we critically appraised the literature on local delivery systems based within the following categories: polymer-based implantable devices, polymeric injectable systems, and hydrogel drug delivery systems. We also discussed the negative effect of hypoxia on treatment strategies and how one might utilize local implantation of oxygen-generating biomaterials as an adjuvant to enhance current therapeutic strategies. This review gives an overview of local drug delivery systems for use in glioblastoma therapeutics, offering insight into the developing field of oxygen-generating biomaterials and their potential to reverse hypoxia-associated radio-resistance.
ISSN:2047-4830
2047-4849
DOI:10.1039/d1bm00896j