HDL-C, longitudinal change and risk of mortality in a Chinese cohort study

High-density lipoprotein cholesterol (HDL-C) concentration and variability are both important factors of cardiovascular disease (CVD) and mortality. We aimed to explore the associations of HDL-C and longitudinal change in HDL-C with risk of mortality. We recruited a total of 69,163 participants aged...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-08, Vol.31 (9), p.2669-2677
Main Authors: Yang, Zong-Ming, Wu, Meng-Yin, Lu, Jie-Ming, Zhu, Yao, Li, Die, Yu, Zhe-Bin, Shen, Peng, Tang, Meng-Ling, Jin, Ming-Juan, Lin, Hong-Bo, Shui, Li-Ming, Chen, Kun, Wang, Jian-Bing
Format: Article
Language:English
Subjects:
Cohort study
HDL-C concentration
Longitudinal change
Mortality
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Summary:High-density lipoprotein cholesterol (HDL-C) concentration and variability are both important factors of cardiovascular disease (CVD) and mortality. We aimed to explore the associations of HDL-C and longitudinal change in HDL-C with risk of mortality. We recruited a total of 69,163 participants aged ≥40 years and had medical examination records of HDL-C during 2010–2014 from the Yinzhou District, Ningbo, China. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. We observed a non-linear association of HDL-C with risks of non-accidental and CVD mortality. Compared with the moderate concentration group (1.4–1.6 mmol/L), HDL-C 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2021.06.004