Low vitamin D levels in follicular fluid, but not in serum, are associated with adverse outcomes in assisted reproduction

• Published in: Archives of gynecology and obstetrics 2022-02, Vol.305 (2), p.505-517
• Main Authors: Muyayalo, Kahindo P., Song, Su, Zhai, Hui, Liu, Hong, Huang, Dong-Hui, Zhou, Hui, Chen, Yang-Jiao, Liao, Ai-Hua
• Format: Article
• Language: English
• Subjects: Clinical outcomes; Drug dosages; Embryos; Endocrinology; Female; Fertilization in Vitro; Follicular Fluid; Gene expression; Gynecologic Endocrinology and Reproductive Medicine; Gynecology; Human Genetics; Humans; Infertility; Infertility, Female - therapy; Medicine; Medicine & Public Health; Menstruation; Metabolism; Obstetrics; Obstetrics/Perinatology/Midwifery; Ovaries; Pharmaceuticals; Pregnancy; Prospective Studies; Reproduction; Reproductive health; Reproductive technologies; Ultrasonic imaging; Vitamin D; Womens health
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-021-06174-9

Purpose To assess the relationship between serum/follicular fluid (FF) vitamin D (VD) status and assisted reproductive technology (ART) treatment outcomes among infertile patients. Methods A prospective cohort study, including 132 infertile patients scheduled for their first ART treatment cycle, was carried out in a Reproductive Medical Center. Serum and FF samples were collected to assess 25-hydroxy VD [25(OH)D] levels. Low VD level was defined as 25(OH)D concentration of less than 30 ng/mL. Results Most infertile patients had low VD levels in serum (88%) and FF (90%). We observed a moderately positive correlation between VD levels in serum and FF ( r  = 0.34, p