Statin gap in patients living with HIV: assessing dose appropriateness

Objectives Patients living with HIV (PLWH) are predisposed to atherosclerotic cardiovascular disease (ASCVD), resulting in concomitant antiretroviral and statin use. A statin prescribing gap for PLWH has been reported, but appropriateness of statin selection and dosing (ASD) has not been described....

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Bibliographic Details
Published in:HIV medicine 2021-11, Vol.22 (10), p.917-923
Main Authors: Pincus, Kathleen J., Blackman, Alison L., Suen, Samuel Y., Devabhakthuni, Sandeep, Gale, Stormi, Noel, Zachary R., Seung, Hyunuk, Pandit, Neha Sheth
Format: Article
Language:English
Subjects:
Adult
Antiretroviral agents
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
atherosclerotic cardiovascular disease
Cardiovascular diseases
Cholesterol
Cholesterol, LDL
Diabetes mellitus
Dosage
Health care facilities
HIV
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
lipids
Patients
Retrospective Studies
Statins
Subgroups
Young Adult
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Summary:Objectives Patients living with HIV (PLWH) are predisposed to atherosclerotic cardiovascular disease (ASCVD), resulting in concomitant antiretroviral and statin use. A statin prescribing gap for PLWH has been reported, but appropriateness of statin selection and dosing (ASD) has not been described. Methods This is a comparative, retrospective study reviewing ASD in PLWH vs. uninfected patients at two outpatient clinics within an academic medical centre. Adults > 21 years old indicated for statin therapy were included. The primary outcome was percentage of PLWH prescribed an appropriately dosed statin, accounting for clinical‐ and patient‐related variables, compared with uninfected patients. The secondary outcome was to identify patient characteristics associated with inappropriately dosed statins. Results After propensity score matching, 879 PLWH and 879 uninfected patients were included for analysis. Fewer PLWH (27.8%, n = 244) were prescribed an ASD compared with uninfected patients (40.5%, n = 356, P 
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.13150