Risk factors of impulsive-compulsive behaviors in PD patients: a meta-analysis

• Published in: Journal of neurology 2022-03, Vol.269 (3), p.1298-1315
• Main Authors: Cao, Lanxiao, Xu, Tian, Zhao, Gaohua, Lv, Dayao, Lu, Jinyu, Zhao, Guohua
• Format: Article
• Language: English
• Subjects: Age; Agonists; Amantadine; Compulsive Behavior - epidemiology; Compulsive Behavior - etiology; Disruptive, Impulse Control, and Conduct Disorders - complications; Dopamine; Dosage; Dyskinesia; Female; Gene polymorphism; Humans; Impulsive Behavior; Levodopa; Male; Medicine; Medicine & Public Health; Meta-analysis; Movement disorders; Neurodegenerative diseases; Neurology; Neuroradiology; Neurosciences; Parkinson Disease - complications; Parkinson Disease - drug therapy; Parkinson Disease - epidemiology; Parkinson's disease; Patients; REM sleep; Review; Risk Factors; Sleep disorders
• ISSN: 0340-5354; 1432-1459
• DOI: 10.1007/s00415-021-10724-1

Objective To summarize the reliable risk factors of impulsive-compulsive behaviors (ICBs) in Parkinson’s disease (PD) patients through a meta-analysis on studies in which PD-ICBs were diagnosed by clinical interview. Methods PubMed, Embase, Web of Science, CNKI and Wanfang databases were searched. We selected studies ensuring that diagnosis of ICBs in PD patients depends on semi-structured interviews according to the clinical diagnostic criteria of ICBs. The Newcastle–Ottawa Scale was used to evaluate quality of the included studies. The analyzed factors included demographic information, clinical characteristics of PD and medications. Results A total of 856 records were screened and 66 full texts were evaluated, and 13 studies (684 PD patients with ICBs [PD-ICBs] and 3,382 PD patients without ICBs [PD-non-ICBs]) were included. Compared with PD-non-ICBs, PD-ICBs were younger in age (− 3.7 [− 5.53, − 1.87], P