High glycosyltransferase 8 domain containing two protein levels contribute to poor prognosis in urothelial carcinoma

Objective To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients. Methods Data mining, immunohistochemistry together with H‐score calculation was carried out to evaluate the glycosyltransferase 8 domain...

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Bibliographic Details
Published in:International journal of urology 2021-11, Vol.28 (11), p.1178-1187
Main Authors: Chen, Tzu‐Ju, Chan, Ti‐Chun, Li, Chien‐Feng, Dilshan Sampath Dissanayaka, Dissanayakage, Kianpour, Maryam, He, Hong‐Lin, Huang, Steven K, Li, Wan‐Shan, Chen, Nai‐Yu, Shiue, Yow‐Ling
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Cancer
Carcinoma, Transitional Cell
Cell adhesion
Collagen
Extracellular matrix
Glycosyltransferase
Glycosyltransferases - genetics
glycosyltransferase 8 domain containing protein 2
Humans
Immunohistochemistry
Medical prognosis
Metastases
Metastasis
molecular pathology
Ontology
Patients
Prognosis
prognostic marker
Proteins
Retrospective Studies
Tumors
Urinary bladder
Urinary Bladder Neoplasms
Urothelial carcinoma
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Summary:Objective To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients. Methods Data mining, immunohistochemistry together with H‐score calculation was carried out to evaluate the glycosyltransferase 8 domain containing protein 2 levels on tissue specimens from urothelial carcinoma patients, retrospectively. Correlations between glycosyltransferase 8 domain containing protein 2 H‐score and imperative clinicopathological factors were measured. The indication of glycosyltransferase 8 domain containing protein 2 level on disease‐specific and metastasis‐free survivals were next analyzed. Results In upper tract urothelial carcinomas (n = 340) and bladder urothelial carcinomas (n = 295), 170 (50%) and 148 (50%) patients, respectively, were identified to have high glycosyltransferase 8 domain containing protein 2 expression. The glycosyltransferase 8 domain containing protein 2 levels were correlated to several clinicopathological characteristics and patient survival. Upregulation of the glycosyltransferase 8 domain containing protein 2 was correlated to primary tumor (P 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.14656