Imbalance between the circulating endothelium-derived apoptotic microparticles and the endothelial colony-forming units of progenitor cells in patients undergoing diagnostic coronary angiography

The involvement of the circulating endothelium-derived microparticles (EMPs) and the endothelial progenitor cells (EPCs) has been shown in the pathogenesis of coronary artery disease (CAD). The current study aimed to explore whether the Friesinger index is associated with the levels of the apoptotic...

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Bibliographic Details
Published in:Advances in medical sciences 2021-09, Vol.66 (2), p.396-402
Main Authors: Pimentel Mota, Isabela Cardoso, Souza, Livia Victorino, Parizotto, Giovanna Pachele, Thomazini, Fernanda, Henao Agudelo, Juan Sebastian, Almeida, Danilo Cândido, Ribamar da Costa Júnior, José, Franco, Maria do Carmo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cell-Derived Microparticles
Coronary Angiography
Coronary artery disease
Endothelial Progenitor Cells
Endothelium, Vascular
Endothelium-derived microparticles
Friesinger index
Humans
Male
Middle Aged
Stem Cells
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Summary:The involvement of the circulating endothelium-derived microparticles (EMPs) and the endothelial progenitor cells (EPCs) has been shown in the pathogenesis of coronary artery disease (CAD). The current study aimed to explore whether the Friesinger index is associated with the levels of the apoptotic CD144+/CD31+/annexin V+ ​EMPs and the number of endothelial colony-forming units of progenitor cells in patients undergoing coronary angiography. Fifty-seven patients with a median age of 62 years (range: 48–84 years) were enrolled. Quantification of the apoptotic CD144+/CD31+/annexin V+ EMPs was performed by flow cytometry. The number of endothelial colony-forming units defined by CFU-Hill was assessed by cell culture. There was a positive correlation between the Friesinger index and the circulating levels of the apoptotic CD144+/CD31+/annexin V+ EMPs (rho=0.817, p
ISSN:1896-1126
1898-4002
DOI:10.1016/j.advms.2021.07.011