Microneedle-Mediated Vaccination: Innovation and Translation

[Display omitted] Vaccine administration by subcutaneous or intramuscular injection is the most commonly prescribed route for inoculation, however, it is often associated with some deficiencies such as low compliance, high professionalism, and risk of infection. Therefore, the application of microne...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2021-12, Vol.179, p.113919-113919, Article 113919
Main Authors: Sheng, Tao, Luo, Bowen, Zhang, Wentao, Ge, Xinyang, Yu, Jicheng, Zhang, Yuqi, Gu, Zhen
Format: Article
Language:English
Subjects:
Drug delivery
Humans
Immunology
Microneedle
Nanoparticles
Needles
Skin - metabolism
Transdermal delivery
Vaccination
Vaccines - administration & dosage
Vaccines - immunology
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Summary:[Display omitted] Vaccine administration by subcutaneous or intramuscular injection is the most commonly prescribed route for inoculation, however, it is often associated with some deficiencies such as low compliance, high professionalism, and risk of infection. Therefore, the application of microneedles for vaccine delivery has gained widespread interests in the past few years due to its high compliance, minimal invasiveness, and convenience. This review focuses on recent advances in the development and application of microneedles for vaccination based on different delivery strategies, and introduces the current status of microneedle-mediated vaccination in clinical translation. The prospects for its application including opportunities and challenges are further discussed.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2021.113919