Associations between GDF15 levels and pre-diabetes in non-obese subjects

Growth differentiation factor 15 (GDF15) is a stress-response cytokine which belongs to the transforming growth factor β superfamily. Although GDF15 was initially found to have a role in metabolic diseases, the association between GDF15 and dysglycemic status remains inconclusive. Thus, the aim of t...

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Bibliographic Details
Published in:Journal of investigative medicine 2022-01, Vol.70 (1), p.79-84
Main Authors: Hung, Hao-Chang, Wu, Hung-Tsung, Lin, Ching-Han, Chou, Hsuan-Wen, Ou, Horng-Yih, Chang, Chih-Jen
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
biomarkers
Blood Glucose - analysis
Blood pressure
Body mass index
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Cholesterol
Creatinine
Cross-Sectional Studies
Cytokines
Diabetes
diabetes mellitus
Diabetes Mellitus - diagnosis
Disease
Female
Glucose
Glucose Intolerance - blood
glucose metabolism disorders
Growth Differentiation Factor 15 - blood
Growth factors
Hemoglobin
High density lipoprotein
Homeostasis
Hospitals
Humans
Hypertension
Insulin resistance
Laboratories
Male
Metabolic disorders
Middle Aged
Obesity
Original research
Physiology
Prediabetic State - blood
Prediabetic State - metabolism
Variance analysis
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Summary:Growth differentiation factor 15 (GDF15) is a stress-response cytokine which belongs to the transforming growth factor β superfamily. Although GDF15 was initially found to have a role in metabolic diseases, the association between GDF15 and dysglycemic status remains inconclusive. Thus, the aim of this study was to examine the relationships between GDF15 and different glycemic statuses in non-obese subjects. We enrolled 502 non-obese subjects, among individuals who had normal glucose tolerance (NGT; n=125), isolated impaired fasting glucose (IFG; n=116), isolated impaired glucose tolerance (IGT; n=106), IFG plus IGT (n=27), and newly diagnosed diabetes (NDD; n=128). A multivariate linear regression analysis of GDF15 levels was used to find independent predictors. The median (IQR) GDF15 levels were 1641.0 (1187.0–1985.5) pg/mL, 1656.1 (1226.8–2379.7) pg/mL, 1487.8 (1145.9–1987.2) pg/mL, 1722.2 (1172.9–1939.0) pg/mL, and 2204.5 (1767.4–2919.1) pg/mL in NGT, IFG, IGT, IFG plus IGT, and NDD groups, respectively. The NDD group had significantly higher GDF15 levels than those with NGT, IFG, IGT, and IFG plus IGT. The IFG group had a significantly higher GDF15 value than the NGT group. In multivariate linear regression analysis, IFG (beta=0.145, 95% CI 192.487 to 740.937, p=0.001), NDD (beta=0.227, 95% CI 390.459 to 888.145, p
ISSN:1081-5589
1708-8267
DOI:10.1136/jim-2021-001805