Determinants of Functional Capacity in Patients with Chagas Disease

Chagas disease leads to reduced functional capacity. However, the stage at which functional impairment is detectable remains unclear. The present study was addressed to compare the functional capacity of patients at different stages of Chagas disease and healthy individuals and to verify the determi...

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Published in:Arquivos brasileiros de cardiologia 2021-11, Vol.117 (5), p.934-941
Main Authors: Silva, Whesley Tanor, Costa, Henrique Silveira, Figueiredo, Pedro Henrique Scheidt, Lima, Márcia Maria Oliveira, Lima, Vanessa Pereira, Costa, Fábio Silva Martins da, Ávila, Matheus Ribeiro, Mendonça, Vanessa Amaral, Lacerda, Ana Cristina Rodrigues, Nunes, Maria Carmo Pereira, Rocha, Manoel Otávio Costa
Format: Article
Language:English
Subjects:
Chagas Cardiomyopathy
Chagas Disease
Cross-Sectional Studies
Diastole
Humans
Male
Stroke Volume
Ventricular Function, Left
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Summary:Chagas disease leads to reduced functional capacity. However, the stage at which functional impairment is detectable remains unclear. The present study was addressed to compare the functional capacity of patients at different stages of Chagas disease and healthy individuals and to verify the determinants of peak oxygen uptake (VO2peak). In a cross-sectional study, 160 individuals were selected, 35 healthy and 125 with Chagas disease. In the Chagasic group, 61 (49%) were in the indeterminate form of the disease, 45 (36%) with Chagas cardiomyopathy (ChC) and preserved cardiac function and 19 (15%) with cardiac dysfunction and dilated ChC. The data were analyzed using univariate and multivariate regression analysis. Statistical significance was set at 5%. Patients in the indeterminate form of disease showed similar functional capacity to healthy individuals (p>0.05). Patients with ChC and preserved cardiac function had lower VO2peak than patients in the indeterminate form (p
ISSN:1678-4170
DOI:10.36660/abc.20200462