MiRNA‐Wnt signaling regulatory network in colorectal cancer

Colorectal cancer (CRC) is one of the common malignancies worldwide and the Wnt signaling pathway is recognized as the main disrupted pathway in this malignancy. MicroRNAs (miRNAs) are recognized to contribute to the pathogenesis of CRC by triggering or impeding the Wnt signaling pathway. In additio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2021-10, Vol.35 (10), p.e22883-n/a
Main Authors: Jafarzadeh, Meisam, Soltani, Bahram M.
Format: Article
Language:English
Subjects:
beta Catenin - genetics
beta Catenin - metabolism
Cancer
cancer management
Carcinogenesis - genetics
Carcinogenesis - metabolism
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Gene Expression Regulation, Neoplastic
Gene regulation
Gene Regulatory Networks
Humans
Literature reviews
Malignancy
mcroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Pathogenesis
Signal transduction
Signaling
Transcription
Tumorigenesis
Wnt protein
Wnt Proteins - genetics
Wnt Proteins - metabolism
Wnt signaling
Wnt Signaling Pathway - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colorectal cancer (CRC) is one of the common malignancies worldwide and the Wnt signaling pathway is recognized as the main disrupted pathway in this malignancy. MicroRNAs (miRNAs) are recognized to contribute to the pathogenesis of CRC by triggering or impeding the Wnt signaling pathway. In addition, transcriptional regulation of miRNAs by canonical Wnt signaling also participates in CRC cell progression. In this review, we present comprehensive literature of the existing data on the interaction of miRNAs and Wnt signaling that could be useful in future studies in the field of CRC management. Highlights The Wnt/β‐catenin signaling plays a pivotal role in colorectal tumorigenesis. Dysregulation of miRNAs impairs the expression of tumor‐suppressive or oncogenic target genes, which is implicated in colorectal cancer pathogenesis. MiRNAs are involved in colorectal cancer progression by modulating the components of the Wnt signaling.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22883