Hemodynamic and Functional Correlates of Concentric vs. Eccentric LVH in a Community-Based Sample With Prevalent Volume-Dependent Hypertension

Abstract BACKGROUND Whether in volume-dependent primary hypertension, concentric left ventricular (LV) remodeling beyond hypertrophy (LVH) represents the impact of a pressure rather than a volume overload, is unclear. METHODS Using central arterial pressure, and aortic velocity and diameter measurem...

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Published in:American journal of hypertension 2021-12, Vol.34 (12), p.1300-1310
Main Authors: Bello, Hamza, Norton, Gavin R, Peterson, Vernice R, Libhaber, Carlos D, Mmopi, Keneilwe N, Mthembu, Nonhlanhla, Masiu, Mohlabani, Da Silva Fernandes, Daniel, Bamaiyi, Adamu J, Peters, Ferande, Sareli, Pinhas, Woodiwiss, Angela J
Format: Article
Language:English
Subjects:
Blood Pressure
Heart Ventricles
Hemodynamics
Humans
Hypertension - complications
Hypertension - diagnostic imaging
Hypertrophy, Left Ventricular - complications
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - epidemiology
Ventricular Remodeling
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Summary:Abstract BACKGROUND Whether in volume-dependent primary hypertension, concentric left ventricular (LV) remodeling beyond hypertrophy (LVH) represents the impact of a pressure rather than a volume overload, is unclear. METHODS Using central arterial pressure, and aortic velocity and diameter measurements in the outflow tract (echocardiography), we determined the factors that associate with concentric LVH or remodeling in a community of African ancestry (n = 709) with prevalent volume-dependent primary hypertension. RESULTS Both left ventricular mass index (LVMI) and relative wall thickness (RWT) were positively and independently associated with end diastolic volume (EDV), stroke volume (SV), and peak aortic flow (Q) (P < 0.05 to
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/hpab128