Comparison of septic and nonseptic pulmonary embolism in children

Background Septic pulmonary embolism (SPE) in children is a rare disease. Data are scarce regarding the clinical and laboratory manifestation of SPE compared with nonseptic pulmonary embolism (ns‐PE). Furthermore, specific guidelines for the management of SPE in children are lacking. Aim We compared...

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Bibliographic Details
Published in:Pediatric pulmonology 2021-10, Vol.56 (10), p.3395-3401
Main Authors: Gatt, Dvir, Ben‐Shimol, Shalom, Hazan, Guy, Golan Tripto, Inbal, Goldbart, Aviv, Aviram, Micha
Format: Article
Language:English
Subjects:
Child
children
Cohort Studies
Humans
Medical imaging
Pediatrics
pulmonary embolism
Pulmonary Embolism - diagnosis
Pulmonary Embolism - drug therapy
Pulmonary embolisms
Rare diseases
Retrospective Studies
Risk Factors
Sepsis - complications
Sepsis - diagnosis
septic emboli
Staphylococcus aureus
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Summary:Background Septic pulmonary embolism (SPE) in children is a rare disease. Data are scarce regarding the clinical and laboratory manifestation of SPE compared with nonseptic pulmonary embolism (ns‐PE). Furthermore, specific guidelines for the management of SPE in children are lacking. Aim We compared the clinical course and outcome of children with SPE and ns‐PE. Methods A retrospective, cohort study of hospitalized children, 2005–2020, with documented pulmonary embolism imaging. Results Sixteen children (eight SPE, eight ns‐PE) were identified. Episodes of SPE occurred secondary to endocarditis, musculoskeletal and soft tissue infections, with Staphylococcus aureus (n = 4) and streptococcus spp. (n = 2) as the most common pathogens. Radiographically, SPE presented as a microvascular disease with parenchymatic nodules/cavitations, whereas ns‐PE presented as larger vessel disease with filling defects. Risk factors (including thrombophilia) were noted in 0% and 87.5% of SPE and ns‐PE patients, respectively (p 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25604