Do gait parameters improve after botulinum toxin injections in post stroke patients? A prospective study

• Published in: Toxicon (Oxford) 2021-09, Vol.200, p.189-197
• Main Authors: Varvarousis, Dimitrios N., Dimopoulos, Dimitris, Vasileiadis, George I., Manolis, Ioannis, Ploumis, Avraam
• Format: Article
• Language: English
• Subjects: Botulinum toxin; Gait analysis; Spasticity; Stroke
• ISSN: 0041-0101; 1879-3150
• DOI: 10.1016/j.toxicon.2021.08.001

The intramuscular injection of botulinum toxin is one of the most efficient ways to treat localized spasticity in patients suffering from Central Nervous System lesions like stroke, cerebral palsy and multiple sclerosis. The gait analysis based on kinetics and kinematics is a recognized way of measurement of the effect of intramuscular injection of botulinum toxin in spastic patients suffering from chronic stroke. The aim of this study is to provide evidence of the beneficial effect of botulinum toxin on characteristics of gait pattern on patients suffering from chronic stroke. So, thirteen patients with spasticity due to chronic stroke were included in the protocol and were treated by botulinum toxin injections in the lower extremity. All patients were evaluated before the injection as well as one month after the botulinum injection on a foot pressure sensitive walkway with a power plate and by the readings of seven inertial measurements units which recorded spatio-temporal specific parameters during walking, and the spasticity was measured according to modified Ashworth Scale. While all spatio-temporal parameters of motion analysis and balance improved for most of the patients after botulinum toxin injection, only one parameter, the normal to hemiplegic step length, reached statistical significant improvement (p