SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia

The relationships of Paired Like Homeodomain 2 (PITX2), Ninjurin 2 (NINJ2), TWIST-Related Protein 1 (TWIST1), Ras Interacting Protein 1 (Rasip1), Solute Carrier Family 17 Member 3 (SLC17A3), Methylmalonyl Co-A Mutase (MUT) and Fer3 Like BHLH Transcription Factor (FERD3L) polymorphisms and gene expre...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2021-10, Vol.30 (10), p.105908-105908, Article 105908
Main Authors: Ching, Shu Chai, Wen, Lim Jing, Ismail, Nor Ismaliza Mohd, Looi, Irene, Kooi, Cheah Wee, Peng, Long Soo, Mui, Lee Soon, Tamibmaniam, Jayashamani, Muninathan, Prema, Hooi, Ong Beng, Ali, Siti Maisarah Md, Hassan, Muhammad Radzi Abu, Mohamad, Mohd Saberi, Griffiths, Lyn R, Wei, Loo Keat
Format: Article
Language:English
Subjects:
Expression
Ischemic stroke
Malaysia
Polymorphism
SLC17A3
SNP
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Summary:The relationships of Paired Like Homeodomain 2 (PITX2), Ninjurin 2 (NINJ2), TWIST-Related Protein 1 (TWIST1), Ras Interacting Protein 1 (Rasip1), Solute Carrier Family 17 Member 3 (SLC17A3), Methylmalonyl Co-A Mutase (MUT) and Fer3 Like BHLH Transcription Factor (FERD3L) polymorphisms and gene expression with ischemic stroke have yet to be determined in Malaysia. Hence, this study aimed to explore the associations of single nucleotide polymorphisms (SNPs) and gene expression with ischemic stroke risk among population who resided at the Northern region of Malaysia. Study subjects including 216 ischemic stroke patients and 203 healthy controls were recruited upon obtaining ethical clearance. SNP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism assays. Gene expression levels were quantified by real-time polymerase chain reaction assays. Statistical and genetic analyses were conducted with SPSS version 22.2, PLINK version 1.07 and multifactor dimensionality reduction software. Study subjects with G allele, CG or GG genotypes of SLC17A3 rs9379800 demonstrated increased risk of ischemic stroke with the odds ratios ranging from 1.76-fold to 3.14-fold (p
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2021.105908