Diagnostic Value of Circular RNA hsa_circ_0002874 Expression in Peripheral Blood of Patients with Gastric Cancer

Abstract The purpose of this study was to determine whether circular RNA hsa_circ_0002874 could serve as a novel biomarker for the diagnosis of gastric cancer (GC). The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastr...

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Bibliographic Details
Published in:Laboratory medicine 2022-01, Vol.53 (1), p.65-70
Main Authors: Sun, Xiaoye, Kong, Shang, Jiang, Chen, Jing, Rongrong, Ju, Shaoqing, Cong, Hui
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor
Cancer
Cancer patients
Diagnosis
Ethylenediaminetetraacetic acid
Gastric cancer
Health savings accounts
Humans
Medical diagnosis
Prognosis
RNA
RNA, Circular
ROC Curve
Stomach cancer
Stomach Neoplasms - diagnosis
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Summary:Abstract The purpose of this study was to determine whether circular RNA hsa_circ_0002874 could serve as a novel biomarker for the diagnosis of gastric cancer (GC). The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastric lesions, and healthy individuals was 3.482 (IQR, 1.524–9.048), 1.261 (IQR, 0.817–2.000), and 1.00 (IQR, 0.726–1.382), respectively, whereas there was no significant difference between the latter 2 groups. The plasma expression level of hsa_circ_0002874 was significantly correlated with tumor stage (U = 234.0; P 
ISSN:0007-5027
1943-7730
DOI:10.1093/labmed/lmab062