Syngeneic hematopoietic stem cell transplantation for aplastic anemia

To evaluate the efficacy of syngeneic hematopoietic stem cell transplantation in the treatment of aplastic anemia. The clinic data of 11 patients with aplastic anemia undergoing syngeneic HSCT were retrospectively analyzed. Among all of the 11 patients with AA, 4 males and 7 females were determined,...

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Bibliographic Details
Published in:Zhōnghuá xuèyèxué zázhì 2021-06, Vol.42 (6), p.474
Main Authors: Zhang, Y, Yang, D L, Zhang, R L, Zhai, W H, Pang, A M, He, Y, Jiang, E L, Feng, S Z, Han, M Z
Format: Article
Language:Chinese
Subjects:
Adult
Anemia, Aplastic - therapy
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Male
Retrospective Studies
Transplantation Conditioning
Young Adult
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Summary:To evaluate the efficacy of syngeneic hematopoietic stem cell transplantation in the treatment of aplastic anemia. The clinic data of 11 patients with aplastic anemia undergoing syngeneic HSCT were retrospectively analyzed. Among all of the 11 patients with AA, 4 males and 7 females were determined, with a median age of 22 (7-44) years old. All of the 11 patients achieved engraftment after the first transplantation: neutrophils engraftment occurred after a median of 10 days (range 8-23) , and platelet engraftment occurred after a median of 11 days (range 8-28) . Eight patients achieved long-term stable engraftment: three patients had graft failure, and two of them underwent secondary transplantation (1 case achieved long-term stable engraftment, but graft failure occurred again after hematopoietic reconstruction in another case) . The median follow-up time was 53 (5-135) months. All of the 11 patients survived, and the blood routine of 9 patients was normal for a long time. Syngeneic hematopoietic stem cell t
ISSN:0253-2727
DOI:10.3760/cma.j.issn.0253-2727.2021.06.006